Results 81 to 90 of about 124,672 (293)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Archetypes

Archetypes are mental structures that are shared among members of a species. They are thought to be innate rather than learnt, and help individuals make sense of and decide what to do about the world.
KOH, Ivy H. Y., LI, Norman P.
  +6 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Possession of Thomas Darling: Adumbrations of a Jungian Psychohistory [PDF]

, 2009
Applying Jungian psychology to this microhistorical instance, I try to understand the potential, psychological significance of Darling?s possession experience. Using the frontispiece ? ?The Witch of Endor? ?
Lu, K
core  

Directional Applicability Analysis of Albedo Retrieval Using Prior BRDF Knowledge

Remote Sensing
Surface albedo measures the proportion of incoming solar radiation reflected by the Earth’s surface. Accurate albedo retrieval from remote sensing data usually requires sufficient multi-angular observations to account for the surface reflectance ...
Hu Zhang, Qianrui Xi, Junqin Xie, Xiaoning Zhang, Lei Chen, Yi Lian, Hongtao Cao, Yan Liu, Lei Cui, Yadong Dong   +9 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Revealing the Archetype: The Journey of a Trecento Madonna and Child at the National Museum of Scotland [PDF]

, 2017
The National Museums Scotland Madonna and Child project sought to uncover and document the history of a fine polychrome wood carving attributed to The Master of the Gualino St Catherine and to prepare it for display. A new body of knowledge has been
Challands, T., De Bellaigue, D., King, R., Palozzi, L., Richter, M., Schwartz, T., Troalen, L., Wong Rueda, M.   +7 more
core   +1 more source

Solving the TTC 2011 Reengineering Case with GReTL

, 2011
This paper discusses the GReTL reference solution of the TTC 2011 Reengineering case. Given a Java syntax graph, a simple state machine model has to be extracted.
Florian Heidenreich, Jürgen Ebert, Jürgen Ebert, Louis Rose, Pieter Van Gorp, Steffen Mazanek, Tassilo Horn, Tassilo Horn, Tassilo Horn   +8 more
core   +2 more sources

Climate-Adaptive Archetypes of Vernacular Villages and Their Application in Public Building Design: A Case Study of a Visitor Center in Chaoshan, China

Buildings
The Sixth Assessment Report of the IPCC highlights that global surface temperatures have risen by 1.1 °C above pre-industrial levels, with a marked increase in the frequency and intensity of extreme heat events in hot–humid regions.
Fengdeng Wan, Ziqiao Li, Huazhao Li, Li Li, Xiaomiao Xiao   +4 more
doaj   +1 more source

Design and quality criteria for archetype analysis

Ecology and Society, 2019
A key challenge in addressing the global degradation of natural resources and the environment is to effectively transfer successful strategies across heterogeneous contexts.
Klaus Eisenack, Sergio Villamayor-Tomas, Graham Epstein, Christian Kimmich, Nicholas Magliocca, David Manuel-Navarrete, Christoph Oberlack, Matteo Roggero, Diana Sietz   +8 more
doaj   +1 more source