Results 81 to 90 of about 37,709 (292)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Directional Applicability Analysis of Albedo Retrieval Using Prior BRDF Knowledge

Remote Sensing
Surface albedo measures the proportion of incoming solar radiation reflected by the Earth’s surface. Accurate albedo retrieval from remote sensing data usually requires sufficient multi-angular observations to account for the surface reflectance ...
Hu Zhang, Qianrui Xi, Junqin Xie, Xiaoning Zhang, Lei Chen, Yi Lian, Hongtao Cao, Yan Liu, Lei Cui, Yadong Dong   +9 more
doaj   +1 more source

Ten archetype set for all 56 counties.

Presented as β color-coded counties in the map of Montana. The first archetype [a] is nearly zero, as it captures the “no disease” state, and acts to “turn-off” the infection/spread in each county. The rest are in order: [b] archetype 2, [c] archetype 3,
Emily Stone (5804144), Sebastian Coombs (17729695), Erin Landguth (3243888)   +2 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Architecture as a process. Metamorphoses of style in the time and space

Проект Байкал
The development of architecture of modernism and postmodernism is considered on the example of brutalism style as an oscillating process between the aspiration to severe truthfulness and the predominance of decorativeness.
Константин Лидин
doaj   +1 more source

ARCHETYPE AND LOGOS OF FURNACE AND FIREPLACE

RUDN Journal of Language Studies, Semiotics and Semantics, 2019
The article is literary in nature: the example of the furnace shows the difference between the logos and the archetype, as well as the principles of modifying the logos into an archetype.
Svetlana V. Gerasimova
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Figure 1. Hypothetical salticid archetype for a in A salticid archetype for salticid spiders

, 2022
Figure 1. Hypothetical salticid archetype for a salticid spider (1) and representatives of five lepidopteran genera that share these archetypal features (2-6), apparently the result of convergent evolution. Attribution and ©: 1, David E.
Hill, David E.
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source