Results 91 to 100 of about 124,672 (293)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
, 2015 Literary authors and performing artists are redefining the image of the Jezebel archetype from a negative stereotype to an empowering persona. The reformation of the Jezebel’s identity and reputation, from a manipulating stereotype to an uplifting ...
Brown, Zakiya A.
core
Architecture as a process. Metamorphoses of style in the time and space
Проект БайкалThe development of architecture of modernism and postmodernism is considered on the example of brutalism style as an oscillating process between the aspiration to severe truthfulness and the predominance of decorativeness.
Константин Лидин
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Comparative Analysis of Resilience by Supply Network Structure [PDF]
, 2015 This research applies Kim, et al.’s (2015) supply network structure archetypes to case data related to two disruptions in three industries in Brazil. A total of seven supply networks were studied, through in-depth interviews and archival documents.
Bradaschia, Marcelo +4 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
, 1996 A parallel program archetype [2] aids in the development of reliable, efficient parallel applications with common computation/communication structures by providing development methods and code libraries specific to the structure.
Davis, Gregg, Massingill, Berna L.
core +1 more source
ARCHETYPE AND LOGOS OF FURNACE AND FIREPLACE
RUDN Journal of Language Studies, Semiotics and Semantics, 2019 The article is literary in nature: the example of the furnace shows the difference between the logos and the archetype, as well as the principles of modifying the logos into an archetype.
Svetlana V. Gerasimova
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source