Results 51 to 60 of about 134,557 (313)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Cadernos Brasileiros de Terapia Ocupacional, 2019 Introduction: This article discusses physical accessibility and possible influences across users of an oncology service. Through the eyes of Occupational Therapy, we consider this as an important aspect before the rehabilitation process of these ...
Laura Bianchetti Galvan +3 more
doaj +1 more source
Multiple-PON access network architecture [PDF]
2nd IET International Conference on Access Technologies, 2006 A novel access network architecture based on a coarse wavelength division multiplexing array waveguide grating router for switching up to 32 optical network units per passive optical network over a single coarse wavelength band is described. The cost effective network architecture is simulated, using a physical-layer model of two passive optical ...
Y. Shachaf, P. Kourtessis, J.M. Senior
openaire +1 more source
The experiment of Community involvement in a project planning within the historical context of Rome city [PDF]
, 2018 The PhD student proposes a method of community involvement in the planning and in the regeneration of historical centers, in support of the city’s accessibility and people’s well-being.
Bozza, Francesca
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Accessibility as a “Key Enabling Knowledge” to Human Development: the Accessibility Plan
Techne, 2014 In Italy, according to Law no. 41/1986 and Law no. 104/1992, public entities must draw up a Plan for Elimination of Architectural Barriers (PEBA). Unfortunately, many years after the introduction of these laws we can see that the PEBA is not yet a ...
Antonio Laurìa
doaj +1 more source
, 2010 The Archigram archival project made the works of seminal experimental architectural group Archigram available free online for an academic and general audience.
Rattenbury, K., Rattenbury, K.
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Hierarchical Management Architecture for Multi-Access Networks [PDF]
2011 IEEE Global Telecommunications Conference - GLOBECOM 2011, 2011 Future Internet will be highly heterogeneous supporting a multitude of access technologies with overlapping coverages. The automation and optimization of network operations like resource, mobility or QoS management in such a multi-access and multi-operator environment becomes a very challenging but vital task in order to ensure smooth network operation
Kliazovich, Dzmitry +5 more
openaire +4 more sources