Results 61 to 70 of about 134,557 (313)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Analysis of the Application of Universal Design Standards to Interior-Architecture Design [PDF]

open access: yes, 2019
A lot of research shows the findings of cases of public facilities that are not accessible to people with disabilities and see the importance of a design especially in the field of architecture-interior that is able to produce a user-friendly and barrier-
Cardiah, T. (Tita )   +4 more
core  

Selected Aspects of the Tourist Space of the Lublin Region (Case Study) [PDF]

open access: yes, 2014
The article presents the results of studies on the tourist space of the Lublin Region conducted so far by employees of the Department of Regional Geography and Tourism at the Faculty of Earth Sciences and Spatial Management of the Maria Curie-Skłodowska ...
Brzezińska-Wójcik, Teresa   +5 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

SOCIAL POLICY IN THE FIELD OF ARCHITECTURAL ACCESSIBILITY FOR PEOPLE WITH LIMITED MOBILITY: INTERNATIONAL EXPERIENCE AND OPPORTUNITIES FOR ADAPTATION IN UKRAINE

open access: yesПублічне управління та регіональний розвиток
The article analyzes the experience of foreign countries in the field of architectural accessibility for people with limited mobility and the possibilities of its adaptation in Ukraine.
Svitlana Surgova, Olena Faichuk
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Acessibilidade aos serviços de saúde: uma análise a partir da Atenção Básica em Pernambuco

open access: yesSaúde em Debate
Analisou-se a acessibilidade aos serviços de saúde de Atenção Básica em Pernambuco e os aspectos que favorecem ou dificultam a entrada e a permanência do usuário no sistema de saúde.
Maria do Socorro Veloso de Albuquerque   +4 more
doaj   +1 more source

Effective workplaces – bridging the gap between architectural research and design practice. [PDF]

open access: yes, 2007
Architectural researchers and design practitioners mostly segregate in distinct communities with hardly any overlap, collaboration or exchange of ideas.
Budgen, A   +4 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Home - About - Disclaimer - Privacy