Results 101 to 110 of about 40,506 (313)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
FANTASY FIGURE IN CREATIVE INDEPENDENT WORK OF STUDENTS-ARCHITECTS
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2017 It is considered that one of the most urgent problems of architectural education - creative development of students in the course of independent work on a drawing class.
V. P. Mamugina
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Editorial Findings in Architectural Composition [PDF]
Poyatos Sebastián, J. (2024). Editorial Findings in Architectural Composition. VLC arquitectura. Research Journal. 11(1):5-7.
Poyatos Sebastian, Javier
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Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Approaches to Computer Aided Architectural Composition
, 1996 We have a pleasure to present a book of texts related to computer use in the field of architectural composition, showing its various aspects. As the field of composition is very wide - the papers represent also a wide spectrum of interests and approaches
A. Asanowicz, A. Jakimowicz
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Requirements for an Architectural Composition Language
, 2002 ADLs are used in Software Engineering to describe the architecture of an application. This description can be used by different tools to support architectural analysis.
Oberleitner, Johann, Gschwind, Thomas
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