Results 81 to 90 of about 40,506 (313)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Broken silhouette of a building: mystique and ethics

open access: yesJournal of Architecture and Urbanism, 2007
The paper aims at revealing the role of a broken silhouette of a building or a group of such buildings representing a hierarchical compositional type in programming ethically significant content in the recipient’s consciousness.
Vytautas Petrušonis
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Ontology transformation and reasoning for model-driven architecture [PDF]

open access: yes, 2005
Model-driven Architecture (MDA) is a software architecture framework proposed by the Object Management Group OMG. MDA emphasises the importance of modelling in the architectural design of service-based software systems.
Claus Pahl, Pahl, Claus
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Style-Based architectural reconfigurations

open access: yes, 2007
We introduce Architectural Design Rewriting (ADR), an approach to the design of reconfigurable software architectures whose key features are: (i) rule-based approach (over graphs); (ii) hierarchical design; (iii) algebraic presentation; and (iv ...
Lluch-Lafuente, Alberto   +7 more
core  

New Geometric Theorems Derived from Integral Equations Applied to Radiative Transfer in Spherical Sectors and Circular Segments

open access: yesMathematics
Semicircles and circular sectors are both ubiquitous in the natural realm. However, mathematically speaking they have represented an enigma since antiquity.
Joseph Cabeza-Lainez
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Kajian Komposisi Sebagai Dasar Pemahaman Bentuk pada Komputasi Perancangan Arsitektur

open access: yesComTech, 2012
Composition and CAAD are closely related to structure logic. Composition is built by numbers which are also the language of CAAD frame algorithm.
Riva Tomasowa
doaj   +1 more source

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