Results 81 to 90 of about 705,550 (337)

Enforcing Architectural Styles in Presence of Unexpected Distributed Reconfigurations

open access: yes, 2012
Architectural Design Rewriting (ADR, for short) is a rule-based formal framework for modelling the evolution of architectures of distributed systems. Rules allow ADR graphs to be refined.
Poyias, Kyriakos, Tuosto, Emilio
core   +2 more sources

Resonances of the Unknown [PDF]

open access: yes, 2011
Purpose – The purpose of this paper is to discuss the relevance of second-order cybernetics for a theory of architectural design and related discourse. Design/methodology/approach – First, the relation of architectural design to the ...
Westermann, Claudia
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Analysis of the current state of the compositional ensemble of Yerevan's central square: challenges and proposed solutions

open access: yesBudownictwo i Architektura
This article explores contemporary challenges related to the spatial environment of public squares, focusing specifically on the architectural ensemble of Yerevan’s Republic Square.
Zhora Sagaryan, Karen Azatyan
doaj   +1 more source

A Pareto Based Genetic Algorithm Model for Sustainable Site Layout Design of Social Housing: SSPM

open access: yesMegaron, 2016
Sustainable architectural design process is more complicated than traditional building design because it has its own regulations that require calculations and comparisons that also need to be considered.
Yazgı Badem Aksoy   +2 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

A Teaching Experiment in Architectural Design Focused on Efficiency: A Study on the Active and Passive Methods of Site Information Acquisition

open access: yesBuildings
An important goal in the reform of architectural design education is to instruct students in ways of acquiring relevant site information quickly and efficiently during a design project, and then integrating that information into their architectural ...
Zhi Qiu   +4 more
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Architectural design of groupware systems: a component-based approach [PDF]

open access: yes, 2002
Different stakeholders in the design of an enterprise information system have their own view on that design. To help produce a coherent design this paper presents a framework that aids in specifying relations between such views.
Guareis de Farias, Cléver Ricardo
core   +7 more sources

Analysing how constraints impact architectural decision-making [PDF]

open access: yes, 2015
Architectural design projects are characterised by a high number of constraints. Along with planning, energy performance and fire safety regulations, current designers have to face constraining factors related to budget, acoustics, orientation, wind ...
De Meyer, Ronald   +2 more
core   +1 more source

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