Results 91 to 100 of about 428,058 (275)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Relationship Between The Creation Abilities and Architectural Design Process- Students of Department of Architecture at University of Sulaimany as a Case study

Sulaimani Journal for Engineering Sciences, 2014
Creating is one of the needs of the mental and physical creation , and architectural design has the intercommunication between science and creation to reach student to the creative level especially in architectural design , this research study the ...
Alan Fraidoon Ali, Chro Mohammed Ali
doaj   +1 more source

Recovering Architectural Variability of a Family of Product Variants

, 2014
A Software Product Line (SPL) aims at applying a pre-planned systematic reuse of large-grained software artifacts to increase the software productivity and reduce the development cost.
Sahraoui, Houari, Seriai, Abdelhak, Shatnawi, Anas   +2 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

SPEM Extension with software process architectural concepts [PDF]

, 2011
International audienceSPEM is a metamodel adopted by the OMG for software processes engineering. For the software process architectures description, SPEM architectural concepts are very insufficient.
Aoussat, Fadila, Mohamed, Ahmed-Nacer, Oussalah, Mourad Chabane   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The University Education in Architectural Engineering Department in Iraq is a Basic Foundation in Sustainable Development for the Society

مجلة النهرين للعلوم الهندسية, 2017
The university education represents one of the civilized basic foundation for societies , for it bears the scientific development flag, as well as it plays fundamental role in serving society, with submitting fundamentals educational and society and ...
Susan Abed Hassan
doaj  

Theoretical Engineering and Satellite Comlink of a PTVD-SHAM System [PDF]

, 2007
This paper focuses on super helical memory system's design, 'Engineering, Architectural and Satellite Communications' as a theoretical approach of an invention-model to 'store time-data'.
Alipour, Philip B.
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The influence of generative AI with prompt engineering on creative design in architectural education

Journal of Asian Architecture and Building Engineering
In architectural education, artificial intelligence (AI) has traditionally been used as a digital design tool, but its role as a pedagogical aid for enhancing creative thinking has been underexplored. This study investigates the integration of generative
Sanghee Lee, Soomin Kang
doaj   +1 more source