Results 91 to 100 of about 4,288,284 (360)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Rationale Management Challenges in Requirements Engineering [PDF]
, 2010 Rationale and rationale management have been playing an increasingly prominent role in software system development mainly due to the knowledge demand during system evaluation, maintenance, and evolution, especially for large and complex systems.
Avgeriou, Paris, +2 more
core +3 more sources
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Software architectures and Open Source Software: Where can research leverage the most? [PDF]
, 2001 Software architectures have been playing a central role in software engineering research for some years now. They are considered of pivotal importance in the success of complex software systems development.
Arief, B., Gacek, C., Lawrie, T.
core
SPIN-ning Software Architectures: A Method for Exploring Complex Systems [PDF]
, 2001 When designing complex software systems that provide multiple non-functional properties, it is usual to try to reuse (and finally compose) simpler existing designs, which deal with each of these properties in solitude.
Issarny, V., Kloukinas, C.
core +1 more source
Section II. Engineering and Architecture [PDF]
Transactions of the Sanitary Institute of Great Britain, 1892 n ...
openaire +3 more sources
From choice architecture to choice engineering [PDF]
Nature Communications, 2019 Qualitative psychological principles are commonly utilized to influence the choices that people make. Can this goal be achieved more efficiently by using quantitative models of choice? Here, we launch an academic competition to compare the effectiveness of these two approaches.
Ohad Dan, Yonatan Loewenstein
openaire +3 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source