Results 71 to 80 of about 572,588 (347)
An Exploratory Approach for Game Engine Architecture Recovery [PDF]
arXiv, 2023 Game engines provide video game developers with a wide range of fundamental subsystems for creating games, such as 2D/3D graphics rendering, input device management, and audio playback. Developers often integrate these subsystems with other applications or extend them via plugins.
arxiv
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Da Vinci -- Architecture-Driven Business Solutions [PDF]
arXiv, 2021 This document has emerged out of Origin's past experiences with architecture-driven application development (AD2), and the need to further formalise and consolidate these experiences.
arxiv
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Architectural reflection for software evolution [PDF]
, 2005 Software evolution is expensive. Lehman identifies several problems associated with it: Continuous adaptation, increasing complexity, continuing growth, and declining quality.
Rank, Stephen
core
Enterprise Architecture Model Transformation Engine
SSRN Electronic Journal, 2021 With increasing linkage within value chains, the IT systems of different companies are also being connected with each other. This enables the integration of services within the movement of Industry 4.0 in order to improve the quality and performance of the processes.
Peter Hillmann +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Architecture, Civil Engineering, EnvironmentIn the design of structures, joint design significantly influences aesthetics, structural performance, tectonics, and member geometry. In this study, a Y-shaped, polyhedral cantilever with fixed joints was transformed into five different trussed ...
Filz Günther H. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source