Results 41 to 50 of about 1,565,190 (299)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Architectural decoration of the eastern frontier

Проект Байкал
The article presents the results of the study conducted by the authors with the support of the grant of the Russian Science Foundation “Military Theme in the Architectural and Spatial Development of the Far East”. Based on the materials of field surveys
Михаил Базилевич, Алина Иванова   +1 more
doaj   +1 more source

Aleatory architectures [PDF]

Granular Matter, 2016
Aleatory architectures explore new approaches and concepts at the intersection of granular materials research and architecture/structural engineering. It explicitly includes stochastic (re-) configuration of individual structural elements and suggests that building materials and components can have their own agency - that they can be designed to adapt ...
Keller, Sean, Jaeger, Heinrich
openaire   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The Structure of Space and Problems of Our Time

Проект Байкал
Since antiquity the image of space as emptiness has been opposed to the image of material space filled with some essence. For a long time this role was played by the theories of ether.
Светлана Головня, Константин Лидин   +1 more
doaj   +1 more source

The Mysteries of Rural Architecture [PDF]

مسکن و محیط روستا, 2010
The rural architecture is all about house it starts with a house and yet it ends with a house. The rural house is quite simple and calm, but in the meanwhile it enjoys some complexity in the sense of wisdom.

doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Intelligent Models and Architectures for Global Learning-Oriented Cooperation

IEEE Access
This paper presents the design of intelligent models and architectures for global learning-oriented cooperation. The research work brings our current investigations towards the definition of a general development methodology for global intelligent ...
Ana M. Gonzalez de Miguel, Antonio Sarasa-Cabezuelo   +1 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source