Results 121 to 130 of about 830,767 (408)
The activity and functions of soil microbial communities in the Finnish sub-Arctic vary across vegetation types [PDF]
, 2022 Sirja Viitamäki +7 more
openalex +1 more source
Microplastics in sea ice and seawater beneath ice floes from the Arctic Ocean
Scientific Reports, 2020 Within the past decade, an alarm was raised about microplastics in the remote and seemingly pristine Arctic Ocean. To gain further insight about the issue, microplastic abundance, distribution and composition in sea ice cores (n = 25) and waters ...
L. D. Kanhai +4 more
semanticscholar +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Polychlorinated biphenyls in air and water of the North Atlantic and Arctic Ocean. [PDF]
, 2008 Air and seawater samples were collected on board the R/V Polarstern during a scientific expedition from Germany to the Arctic Ocean during June–August 2004.
Dachs, Jordi +7 more
core +3 more sources
Understanding Arctic Ocean Circulation: A Review of Ocean Dynamics in a Changing Climate
, 2020 12 The Arctic Ocean is a focal point of climate change, with ocean warming, freshening, 13 sea-ice decline and circulation that link to the changing atmospheric and terrestrial en14 vironment. Major features of the Arctic and the interconnected nature of
M. Timmermans, J. Marshall
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Development of automated system for receiving and analysing telemetry data from small spacecrafts [PDF]
E3S Web of ConferencesThe system presented in the study is designed to increase the share of automation in the process of interaction with small spacecraft (SSС) at all stages of operation.
Aleshko Roman +3 more
doaj +1 more source
Breaking Barriers to Renewable Energy Production in the North American Arctic [PDF]
, 2018 As climate change continues to affect our lives, the communities at the northern extremes of our world have witnessed the changes most profoundly. In the Arctic, where climate change is melting permafrost and causing major shoreline erosion, remote ...
Strand, Henrik
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source