Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Seasonal variation of the transport of black carbon aerosol from the Asian continent to the Arctic during the ARCTAS aircraft campaign [PDF]
, 2011 Extensive measurements of black carbon (BC) aerosol were conducted in and near the North American Arctic during the Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) aircraft campaign in April and June-July 2008.
Blake, DR +11 more
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Development of a methodology for automated processing of spatial data of agricultural land based on machine learning [PDF]
E3S Web of ConferencesAgriculture industry in Russia is an important part of the economy. Therefore, this industry must be highly efficient and profitable. The usage of remote sensing data for field monitoring makes it possible to simplify the process of collecting ...
Berezovsky Vladimir +3 more
doaj +1 more source
How tropical Pacific surface cooling contributed to accelerated sea ice melt from 2007 to 2012 as ice is thinned by anthropogenic forcing [PDF]
, 2019 Over the past 40 years the Arctic sea ice minimum in September has declined. The period between 2007 and 2012 showed accelerated melt contributed to the record minima of 2007 and 2012.
Baxter, Ian
core
Analysis of ozone and nitric acid in spring and summer Arctic pollution using aircraft, ground-based, satellite observations and MOZART-4 model: source attribution and partitioning [PDF]
, 2012 In this paper, we analyze tropospheric O_3 together with HNO_3 during the POLARCAT (Polar Study using Aircraft, Remote Sensing, Surface Measurements and Models, of Climate, Chemistry, Aerosols, and Transport) program, combining observations and model ...
Batchelor, R. L. +16 more
core +4 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Insignificant effect of Arctic amplification on the amplitude of midlatitude atmospheric waves
Science Advances, 2020 We find no evidence from observations or climate models that Arctic amplification causes a wavier midlatitude circulation. Whether Arctic amplification has contributed to a wavier circulation and more frequent extreme weather in midlatitudes remains an ...
R. Blackport, J. Screen
semanticscholar +1 more source
Foxes and food subsidies: anthropogenic food use by red and Arctic foxes, and effects on Arctic fox survival, on the Arctic Coastal Plain of Alaska [PDF]
, 2013 Thesis (M.S.) University of Alaska Fairbanks, 2013Food subsidies have the potential to impact wildlife on the Arctic Coastal Plain of Alaska. Red foxes (Vulpes vulpes (L., 1758)) expanded their range into Arctic regions during the 20th century, and the ...
Savory, Garrett
core