Results 181 to 190 of about 830,767 (408)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Mitigation of Arctic Tundra Surface Warming by Plant Evapotranspiration: Complete Energy Balance Component Estimation Using LANDSAT Satellite Data [PDF]
, 2020 Václav Nedbal, Kamil Láska, Jakub Brom
openalex +1 more source
Variability modes of September Arctic sea ice: drivers and their contributions to sea ice trend and extremes [PDF]
, 2023 Mehdi Pasha Karami +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
Interactive tables in the wild - visitor experiences with multi-touch tables in the Arctic exhibit at the Vancouver Aquarium [PDF]
, 2015 Funding: Alberta Innovates–Technology Futures (Alberta Ingenuity & iCORE), CFI, NSERC, and SMART Technologies.This report describes and discusses the findings from a field study that was conducted at the Vancouver Aquarium to investigate how visitors ...
Carpendale, Sheelagh, Hinrichs, Uta
core
Eyes of the world on a warmer, less frozen, and greener Arctic [PDF]
, 2023 Gerald V. Frost +6 more
openalex +1 more source
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
Significant parameters of mining properties in arctic and subarctic areas of North America [PDF]
, 1983 Editors: Bruce W. Campbell and John J. DiMarchiThis paper is a review of those factors unique to mining in the Arctic and subarctic. The information was developed from an exhaustive Literature search and personal visits to several northern mines in ...
Hackney, D.A., Lambert, C.
core
Annals of Clinical and Translational Neurology, EarlyView.Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo +13 more
wiley +1 more source
Sustainable Development, Natural Resource Extraction, and the Arctic: The Road Ahead [PDF]
, 2016 Sustainable development has emerged as an integral nexus, linking together critically important global issues including environmental stewardship and economic growth. Understanding sustainable development demands a close analysis of evolving definitions,
Canuel, Edward
core +1 more source