Results 51 to 60 of about 647,466 (361)

Taking stock of arctic sea ice and climate [PDF]

, 2009
The relationship among the cause-and-effect of the Arctic atmosphere, sea ice, and ocean is discussed. The increased vulnerability of the Arctic system to anomalous atmospheric forcing can be argued from the perspective that recent ice loss is the result
Francis, Jennifer, Hamilton, Lawrence C., Proshutinsky, Audrey, Timmermans, Mary-Louise   +3 more
core   +2 more sources

Potential for flexible lactate shuttling between astrocytes and neurons to mitigate against diving-induced hypoxia

Frontiers in Neuroanatomy
For most non-diving mammals, lack of O2 (hypoxia) has detrimental effects on brain function. Seals, however, display a series of systemic, cellular, and molecular adaptations that enable them to tolerate repeated episodes of severe hypoxia.
Chiara Ciccone, Sari Elena Dötterer, Sigrid Vold Jensen, Cornelia Geßner, Alexander C. West, Shona H. Wood, David G. Hazlerigg, Lars P. Folkow   +7 more
doaj   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Advancing hyperspectral imaging techniques for root systems: a new pipeline for macro- and microscale image acquisition and classification

Plant Methods
Background Understanding the environmental impacts on root growth and root health is essential for effective agricultural and environmental management.
Corine Faehn, Grzegorz Konert, Markku Keinänen, Katja Karppinen, Kirsten Krause   +4 more
doaj   +1 more source

The Useless Arctic: Exploiting Nature in the Arctic in the 1870s

Nordlit, 2015
<p align="LEFT">What is the discursive genealogy of an ecological approach to the Arctic? Building on distinctions suggested by Francis Spufford and Gísli Pálsson, this article examines a specific juncture in the history of European–Arctic interaction – the reception of the Austro-Hungarian Arctic Expedition in 1874 – and traces the potential for
Spring, Ulrike, Schimanski, Johan Henrik
openaire   +8 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Arctic warming and your weather: Public belief in the connection [PDF]

, 2013
Will Arctic warming affect mid-latitude weather? Many researchers think so, and have addressed this question through scientific articles and news media. Much of the public accepts such a connection as well.
Hamilton, Lawrence C., Lemcke-Stampone, Mary D.   +1 more
core   +1 more source

Development of automated system for receiving and analysing telemetry data from small spacecrafts [PDF]

E3S Web of Conferences
The system presented in the study is designed to increase the share of automation in the process of interaction with small spacecraft (SSС) at all stages of operation.
Aleshko Roman, Gordeychik Alexander, Berezovsky Vladimir, Shoshina Ksenia   +3 more
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Arctic in Rapid Transition (ART) : science plan [PDF]

, 2010
The Arctic is undergoing rapid transformations that have brought the Arctic Ocean to the top of international political agendas. Predicting future conditions of the Arctic Ocean system requires scientific knowledge of its present status as well as a ...
Forest, Alexandre, Forwick, Matthias, Frey, Karen, Mathis, Jeremy, Michel, Christine, Nikolopoulos, Anna, O'Regan, Matt, Peeken, Ilka, Reigstad, Marit, Wegner, Carolyn   +9 more
core