Results 71 to 80 of about 680,036 (364)

Analysis of ozone and nitric acid in spring and summer Arctic pollution using aircraft, ground-based, satellite observations and MOZART-4 model: source attribution and partitioning [PDF]

, 2012
In this paper, we analyze tropospheric O_3 together with HNO_3 during the POLARCAT (Polar Study using Aircraft, Remote Sensing, Surface Measurements and Models, of Climate, Chemistry, Aerosols, and Transport) program, combining observations and model ...
Batchelor, R. L., Clerbaux, C., Coffey, M. T., Coheur, P. -F., Crounse, J. D., Edwards, D. P., Emmons, L., Hannigan, J., Hurtmans, D., Lindenmaier, R., Nowak, J. B., Ryerson, T. B., Saunois, M., Strong, K., Weinheimer, A. J., Wennberg, P. O., Wespes, C.   +16 more
core   +4 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Persistent pain associated with socioeconomic and personal factors in a Sami and Non-Sami population in Norway: an analysis of SAMINOR 2 survey data

International Journal of Circumpolar Health, 2020
In international studies, higher prevalence of persistent pain has been reported in indigenous populations compared to majority populations. The present study aimed to determine the prevalence of persistent pain within a Sami and a non-Sami population in
Elin Damsgård, Gyrd Thrane, Nils Fleten, Johan Bagge, Tore Sørlie, Audny Anke, Ann-Ragnhild Broderstad   +6 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Comprehensive study of old ice ridges in the Arctic Ocean

Лëд и снег, 2020
In May 2015, a comprehensive study of an old ice ridge was carried out to the north of Bennett Island in the East-Siberian Sea with application of water thermal drilling, tachometric and sonar surveys, video survey by the underwater device and methods ...
Roman B. Guzenko, Yevgeny U. Mironov, Victor V. Kharitonov, Stepan V. Khotchenkov, Ruslan I. May, Viktor S. Porubaev, Sergey M. Кovalеv, Konstantin А. Kornishin, Yaroslav О. Efimov   +8 more
doaj  

Substrate and Topsoil Impact on Soil Water and Soil Temperature in Arctic Diamond Mine Reclamation [PDF]

, 2022
Amalesh Dhar, Valerie Miller, S. R. Wilkinson, M. Anne Naeth   +3 more
openalex   +1 more source

The large‐scale freshwater cycle of the Arctic [PDF]

, 2006
This paper synthesizes our understanding of the Arctic\u27s large‐scale freshwater cycle. It combines terrestrial and oceanic observations with insights gained from the ERA‐40 reanalysis and land surface and ice‐ocean models. Annual mean freshwater input
Aagaard, Knut, Barrett, Andrew P., Lammers, Richard B., Lee, Craig M., Meredith, Michael, Moritz, Richard, Serreze, Mark C., Slater, Andrew G., Steele, Michael, Woodgate, Rebecca A.   +9 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Potential for flexible lactate shuttling between astrocytes and neurons to mitigate against diving-induced hypoxia

Frontiers in Neuroanatomy
For most non-diving mammals, lack of O2 (hypoxia) has detrimental effects on brain function. Seals, however, display a series of systemic, cellular, and molecular adaptations that enable them to tolerate repeated episodes of severe hypoxia.
Chiara Ciccone, Sari Elena Dötterer, Sigrid Vold Jensen, Cornelia Geßner, Alexander C. West, Shona H. Wood, David G. Hazlerigg, Lars P. Folkow   +7 more
doaj   +1 more source

Arctic in Rapid Transition (ART) : science plan [PDF]

, 2010
The Arctic is undergoing rapid transformations that have brought the Arctic Ocean to the top of international political agendas. Predicting future conditions of the Arctic Ocean system requires scientific knowledge of its present status as well as a ...
Forest, Alexandre, Forwick, Matthias, Frey, Karen, Mathis, Jeremy, Michel, Christine, Nikolopoulos, Anna, O'Regan, Matt, Peeken, Ilka, Reigstad, Marit, Wegner, Carolyn   +9 more
core