Results 71 to 80 of about 211,120 (341)
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Simultaneous Oxidation of Atmospheric Methane, Carbon Monoxide and Hydrogen for Bacterial Growth
Microorganisms, 2021 The second largest sink for atmospheric methane (CH4) is atmospheric methane oxidizing-bacteria (atmMOB). How atmMOB are able to sustain life on the low CH4 concentrations in air is unknown.
Alexander Tøsdal Tveit +5 more
doaj +1 more source
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Известия Томского политехнического университета: Инжиниринг георесурсов, 2020 The relevance of the research consists in determining the age of mollusks in the Green fjord bay of West Spitsbergen Island and physical and chemical parameters of their habitant environment in conditions of the threat of destruction of geological ...
Vidas V. Kriauciunas +6 more
doaj +1 more source
A Benchmark Model for Fixed-Target Arctic Sea Ice Forecasting [PDF]
arXiv, 2021 We propose a reduced-form benchmark predictive model (BPM) for fixed-target forecasting of Arctic sea ice extent, and we provide a case study of its real-time performance for target date September 2020. We visually detail the evolution of the statistically-optimal point, interval, and density forecasts as time passes, new information arrives, and the ...
arxiv
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
Rapid loss of Arctic sea ice [PDF]
arXiv, 2022 Several environmental tipping points and self-reinforcing feedback loops are still disregarded within the frequently used climate models. Thus, existing climate models are not very representative for providing projections of the conditions after the actual environmental tipping points are triggered.
arxiv
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
A refined method to monitor arousal from hibernation in the European hamster
BMC Veterinary Research, 2021 Background Hibernation is a physiological and behavioural adaptation that permits survival during periods of reduced food availability and extreme environmental temperatures.
Fredrik A. F. Markussen +5 more
doaj +1 more source