Results 81 to 90 of about 647,466 (361)

The Arctic [PDF]

Bulletin of the American Meteorological Society, 2021
Druckenmiller, Matthew, Moon, Twila, Thoman, Richard, Ballinger, Thomas, Berner, Logan, Bernhard, Germar, Bhatt, Uma, Bjerke, Jarle, Box, Jason, Brown, R., Cappelen, John, Christiansen, Hanne, Decharme, Bertrand, Derksen, C., Divine, Dmitry, Drozdov, D., Elias Chereque, A., Epstein, Howard, Farquharson, L., Farrell, Sinead, Fausto, Robert, Fettweis, Xavier, Fioletov, Vitali, Forbes, Bruce, Frost, Gerald, Gargulinski, Emily, Gerland, Sebastian, Goetz, Scott, Grabinski, Z., Grooss, Jens-Uwe, Haas, Christian, Hanna, Edward, Hanssen-Bauer, Inger, Hendricks, Stefan, Holmes, Robert, Ialongo, Iolanda, Isaksen, K., Jain, Piyush, Johnsen, Bjørn, Kaleschke, L., Kholodov, A., Kim, Seong-Joong, Korsgaard, Niels, Labe, Zachary, Lakkala, Kaisa, Lara, Mark, Loomis, Bryant, Luojus, K., Macander, Matthew, Malkova, G., Mankoff, Kenneth, Manney, Gloria, Mcclelland, James, Meier, Walter, Mote, Thomas, Mudryk, L., Müller, Rolf, Nyland, K., Overland, James, Park, T., Pavlova, Olga, Perovich, Don, Petty, Alek, Phoenix, Gareth, Raynolds, Martha, Reijmer, C., Richter-Menge, Jacqueline, Ricker, Robert, Romanovsky, Vladimir, Scott, Lindsay, Shapiro, Hazel, Shiklomanov, Alexander, Shiklomanov, Nikolai, Smeets, C., Smith, Sharon, Soja, Amber, Spencer, Robert, Starkweather, Sandy, Streletskiy, Dimitri, Suslova, Anya, Svendby, Tove, Tank, Suzanne, Tedesco, Marco, Tian-Kunze, X., Timmermans, Mary-Louise, Tømmervik, Hans, Tretiakov, Mikhail, Tschudi, Mark, Vakhutinsky, Sofia, van As, Dirk, van de Wal, R., Veraverbeke, Sander, Walker, Donald, Walsh, John, Wang, Muyin, Webster, Melinda, Winton, Øyvind, Wood, K., York, Alison, Ziel, Robert   +99 more
openaire   +4 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Flux of nutrients from Russian rivers to the Arctic Ocean: Can we establish a baseline against which to judge future changes? [PDF]

, 2000
Climate models predict significant warming in the Arctic in the 21st century, which will impact the functioning of terrestrial and aquatic ecosystems as well as alter land‐ocean interactions in the Arctic.
Gordeev, V. V., Holmes, R. M., Lammers, Richard B., Meybeck, M., Peterson, B. J., Vorosmarty, Charles J., Zhulidov, A. V.   +6 more
core   +1 more source

Interaction webs in arctic ecosystems: Determinants of arctic change? [PDF]

Ambio, 2017
How species interact modulate their dynamics, their response to environmental change, and ultimately the functioning and stability of entire communities. Work conducted at Zackenberg, Northeast Greenland, has changed our view on how networks of arctic biotic interactions are structured, how they vary in time, and how they are changing with current ...
Schmidt, Niels M., Hardwick, Bess, Gilg, Olivier, Høye, Toke Thomas, Krogh, Paul Henning, Meltofte, Hans, Michelsen, Anders, Mosbacher, Jesper B., Raundrup, Katrine, Reneerkens, Jeroen, Stewart, Lærke, Wirta, Helena, Roslin, Tomas   +12 more
openaire   +8 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Arctic system on trajectory to new state [PDF]

, 2005
The Arctic system is moving toward a new state that falls outside the envelope of glacial-interglacial fluctuations that prevailed during recent Earth history.
Benner, Ronald, Carmack, Eddy C., Chapin, F. Stuart, III, Francis, Jennifer A., Gerlach, S. Craig, Hamilton, Lawrence C., Hinzman, Larry D., Holland, Marika, Huntington, Henry P., Key, Jeffrey R., Lloyd, Andrea H., McDonald, Glen M., McFadden, Joe, Noone, David, Overpeck, Jonathan T., Perovich, Donald K., Prowse, Terry D., Schlosser, Peter, Serreze, Mark C., Sturm, Matthew   +19 more
core   +2 more sources

Evolution of climate, glaciation and subglacial environments of Antarctica from the deep ice core and Lake Vostok water sample studies (Key results of implementation of the Russian Science Foundation project, 2014–2016)

Лëд и снег, 2017
Work on the project focused on the following five areas: 1)  field works in Antarctica at Vostok and Concordia stations; 2)  experimental and theoretical studies in the field of ice core and paleoclimate research; 3) experimental and theoretical works ...
V. Ya. Lipenkov, A. A. Ekaykin, I. A. Alekhina, Yu. A. Shibaev, A. V. Kozachek, D. O. Vladimirova, N. I. Vasilev, A. V. Preobrazhenskaya   +7 more
doaj   +1 more source

NEW PALEOGEOGRAPHY DATA OF THE EASTERN COAST OF GREEN FJORD (WEST SPITSBERGEN ISLAND) BASED ON RESEARCH OF THE HOLOCENE DEPOSITS ON FINNESET CAPE WITH USE OF ISOTOPE-GEOCHEMICAL METHODS

Известия Томского политехнического университета: Инжиниринг георесурсов, 2020
The relevance of the research consists in determining the age of mollusks in the Green fjord bay of West Spitsbergen Island and physical and chemical parameters of their habitant environment in conditions of the threat of destruction of geological ...
Vidas V. Kriauciunas, Stanislav A. Iglovsky, Artem A. Lyubas, Irina A. Kuznetsova, Ekaterina I. Kotova, Evgeniya V. Shakhova, Kirill A. Mironenko   +6 more
doaj   +1 more source

A refined method to monitor arousal from hibernation in the European hamster

BMC Veterinary Research, 2021
Background Hibernation is a physiological and behavioural adaptation that permits survival during periods of reduced food availability and extreme environmental temperatures.
Fredrik A. F. Markussen, Vebjørn J. Melum, Béatrice Bothorel, David G. Hazlerigg, Valérie Simonneaux, Shona H. Wood   +5 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source