Results 81 to 90 of about 211,120 (341)
Interaction webs in arctic ecosystems: Determinants of arctic change? [PDF]
Ambio, 2017 How species interact modulate their dynamics, their response to environmental change, and ultimately the functioning and stability of entire communities. Work conducted at Zackenberg, Northeast Greenland, has changed our view on how networks of arctic biotic interactions are structured, how they vary in time, and how they are changing with current ...
Schmidt, Niels M. +12 more
openaire +8 more sources
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Bayesian Inference of Spatio-Temporal Changes of Arctic Sea Ice [PDF]
arXiv, 2020 Arctic sea ice extent has drawn increasing interest and alarm from geoscientists, owing to its rapid decline. In this article, we propose a Bayesian spatio-temporal hierarchical statistical model for binary Arctic sea ice data over two decades, where a latent dynamic spatio-temporal Gaussian process is used to model the data-dependence through a logit ...
arxiv
Unraveling the metastasis‐preventing effect of miR‐200c in vitro and in vivo
Molecular Oncology, Volume 19, Issue 4, Page 1029-1053, April 2025.Advanced tumors and ineffective cancer treatments can lead to metastases in distant organs. The sole expression of microRNA 200c (miR‐200c) in breast cancer cells is shown to significantly reduce metastasis formation in xenograft mouse models. Various in vitro analyses revealed impeded migratory behavior, upon miR‐200c expression, as one prerequisite ...
Bianca Köhler +12 more
wiley +1 more source
Probability Assessments of an Ice-Free Arctic: Comparing Statistical and Climate Model Projections [PDF]
arXiv, 2019 The downward trend in the amount of Arctic sea ice has a wide range of environmental and economic consequences including important effects on the pace and intensity of global climate change. Based on several decades of satellite data, we provide statistical forecasts of Arctic sea ice extent during the rest of this century. The best fitting statistical
arxiv
Optimal Combination of Arctic Sea Ice Extent Measures: A Dynamic Factor Modeling Approach [PDF]
arXiv, 2020 The diminishing extent of Arctic sea ice is a key indicator of climate change as well as an accelerant for future global warming. Since 1978, Arctic sea ice has been measured using satellite-based microwave sensing; however, different measures of Arctic sea ice extent have been made available based on differing algorithmic transformations of the raw ...
arxiv
Molecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang +6 more
wiley +1 more source
Arctic Sea Ice State Estimation From Thermodynamic PDE Model [PDF]
arXiv, 2019 Recent rapid loss of the Arctic sea ice motivates the study of the Arctic sea ice thickness. Global climate model that describes the ice's thickness evolution requires an accurate spatial temperature profile of the Arctic sea ice. However, measuring the complete temperature profile is not feasible within and throughout the Arctic icecap.
arxiv
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue 5, Page 1532-1545, May 2025.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source