Results 81 to 90 of about 680,036 (364)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

2017 State-of the Science of Dispersants and Dispersed Oil (DDO) in U.S. Arctic Waters: Degradation and Fate [PDF]

, 2017
Chemical dispersants were employed on an unprecedented scale during the Deepwater Horizon oil spill in the Gulf of Mexico, and could be a response option should a large spill occur in Arctic waters. The use of dispersants in response to that spill raised
Coastal Response Research Center (CRRC)
core   +1 more source

Seasonal variation of the transport of black carbon aerosol from the Asian continent to the Arctic during the ARCTAS aircraft campaign [PDF]

, 2011
Extensive measurements of black carbon (BC) aerosol were conducted in and near the North American Arctic during the Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) aircraft campaign in April and June-July 2008.
Blake, DR, Diskin, G, Fuelberg, HE, Koike, M, Kondo, Y, Matsui, H, Moteki, N, Sahu, LK, Sessions, WR, Takegawa, N, Wisthaler, A, Zhao, Y   +11 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Safeguarding Important Areas in the U.S. Arctic Ocean [PDF]

, 2015
The U.S. Arctic Ocean supports unique species found nowhere else in the country and is home to indigenous Inupiat people who have thrived on its bounty for thousands of years.

core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Development of the technology of a new flour culinary fish product enriched with iodine of the White Sea kelp

Vestnik MGTU
The range of fish culinary products has been selected based on the analysis of consumer motivation in Murmansk and current trends in the development of the regional fish culinary products market.
Savkina K. N., Cshetinsky V. V., Tihonova P. A., Shokina Yu. V.   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

The prospective development of Climate and Environmental Research Laboratory of AARI, Roshydromet, after gaining the grant of Russian Science Foundation

Лëд и снег, 2015
In November 2010 a new research unit was inaugurated in Arctic and Antarctic Research Institute (St. Petersburg) – Climate and Environmental Research Laboratory (CERL) – that became the first lab in Russia dedicated to the complex studies of ice cores ...
V. Ya. Lipenkov, A. A. Ekaykin, Yu. A. Shibaev, I. A. Alekhina, A. V. Preobrazhenskaya, A. V. Kozachek, D. O. Vladimirova   +6 more
doaj   +1 more source

The tipping times in an Arctic sea ice system under influence of extreme events

, 2020
In light of the rapid recent retreat of Arctic sea ice, the extreme weather events triggering the variability in Arctic ice cover has drawn increasing attention.
Duan, Jinqiao, Fu, Ling, Wiggins, Stephen, Yang, Fang, Zheng, Yayun   +4 more
core   +1 more source