Results 51 to 60 of about 2,416 (260)

Towards the Optimal Management of the Northeast Arctic Cod Fishery [PDF]

SSRN Electronic Journal, 2011
The objectives pursued by governments managing fisheries may include maximizing profits, minimizing the impact on the marine ecosystem, or securing employment, which all require adjusting the composition of the fishing fleet. We develop a management plan that can be adapted to those objectives and allows the regulator to compare the long-run profits ...
Richter, Andries, Eikeset, Anne Maria, Soest, Daan van, Stenseth, Nils Chr.   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mesopelagic Sound Scattering Layers of the High Arctic: Seasonal Variations in Biomass, Species Assemblage, and Trophic Relationships

Frontiers in Marine Science, 2019
Mesopelagic sound scattering layers (SSL) are ubiquitous in all oceans. Pelagic organisms within the SSL play important roles as prey for higher trophic levels and in climate regulation through the biological carbon pump.
Maxime Geoffroy, Maxime Geoffroy, Malin Daase, Marine Cusa, Gérald Darnis, Martin Graeve, Néstor Santana Hernández, Jørgen Berge, Jørgen Berge, Paul E. Renaud, Paul E. Renaud, Finlo Cottier, Finlo Cottier, Stig Falk-Petersen, Stig Falk-Petersen   +14 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Acclimation potential of Arctic cod (Boreogadus saida Lepechin) from the rapidly warming Arctic Ocean [PDF]

Journal of Experimental Biology, 2016
In consequence of the growing concern with warming of the Arctic Ocean, this study quantified the thermal acclimation responses of Boreogadus saida, a key Arctic food web fish. Physiological rates for cardio-respiratory functions as well as critical maximum temperature (Tcmax) for loss of equilibrium (LOE) were measured. The transition temperatures for
H. E. Drost, M. Lo, E. C. Carmack, A. P. Farrell   +3 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Embryonic Crude Oil Exposure Impairs Growth and Lipid Allocation in a Keystone Arctic Forage Fish

iScience, 2019
Summary: As Arctic ice recedes, future oil spills pose increasing risk to keystone species and the ecosystems they support. We show that Polar cod (Boreogadus saida), an energy-rich forage fish for marine mammals, seabirds, and other fish, are highly ...
Benjamin J. Laurel, Louise A. Copeman, Paul Iseri, Mara L. Spencer, Greg Hutchinson, Trond Nordtug, Carey E. Donald, Sonnich Meier, Sarah E. Allan, Daryle T. Boyd, Gina M. Ylitalo, James R. Cameron, Barbara L. French, Tiffany L. Linbo, Nathaniel L. Scholz, John P. Incardona   +15 more
doaj   +1 more source

Polar cod in jeopardy under the retreating Arctic sea ice [PDF]

Communications Biology, 2019
AbstractThe Arctic amplification of global warming is causing the Arctic-Atlantic ice edge to retreat at unprecedented rates. Here we show how variability and change in sea ice cover in the Barents Sea, the largest shelf sea of the Arctic, affect the population dynamics of a keystone species of the ice-associated food web, the polar cod (Boreogadus ...
Mats Brockstedt Olsen Huserbråten, Elena Eriksen, Harald Gjøsæter, Frode Vikebø   +3 more
openaire   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source