Results 71 to 80 of about 2,573 (256)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Results of complex surveys in the East Siberian Sea in August 2015
Известия ТИНРО, 2016 Data on oceanographic conditions, composition of plankton communities, benthic and demersal fish and invertebrates in the southern East Siberian Sea are presented by results of the complex survey conducted in August 2015, The bottom trawl survey assessed
Igor I. Glebov +6 more
doaj +1 more source
Fisheries-induced evolution in Northeast Arctic cod
, 2005 We explore the evolutionary effects of fisheries on North-East Arctic (NEA) cod. It has earlier been shown that fisheries can change the cod’s age and size at maturation in two ways: first, by reducing the biomass, which may lead to faster individual growth and thereby earlier maturation (through phenotypic plasticity), and secondly, by altering the ...
Eikeset, Anne Maria +2 more
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Arctic ScienceConsidering seabirds as indicators of environmental change, we compared thick-billed murre (Uria lomvia (Linnaeus, 1758)) adult and chick diet in the North Water polynya region, NW Greenland, during 1997 and 2023.
Knud Falk +8 more
doaj +1 more source
Embryonic Crude Oil Exposure Impairs Growth and Lipid Allocation in a Keystone Arctic Forage Fish
iScience, 2019 Summary: As Arctic ice recedes, future oil spills pose increasing risk to keystone species and the ecosystems they support. We show that Polar cod (Boreogadus saida), an energy-rich forage fish for marine mammals, seabirds, and other fish, are highly ...
Benjamin J. Laurel +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Results of multidisciplinary survey in the Laptev Sea in August-September, 2015
Известия ТИНРО, 2016 Data on oceanographic conditions and species composition of plankton, benthic and demersal fish and invertebrates are presented, obtained in the complex survey over the external shelf of the Laptev Sea in August-September 2015.
Igor I. Glebov +6 more
doaj +1 more source