Results 71 to 80 of about 2,466 (257)

A shift in foraging behaviour of beluga whales Delphinapterus leucas from the threatened Cumberland Sound population may reflect a changing Arctic food web

Endangered Species Research, 2016
Cumberland Sound, an inlet on Baffin Island, Nunavut, Canada, is undergoing changes in sea ice cover, which is affecting the marine food web. A small population of beluga whales Delphinapterus leucas inhabits Cumberland Sound year round and this ...
Watt, CA, Orr, J, Ferguson, SH
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Barren depths from 82° N to the North Pole reveal scarcity of fish in the Central Arctic Ocean

Communications Earth & Environment
The Arctic Ocean is changing from ice-covered to open water in summer, with boreal species expanding northwards. We conducted a ship-based marine ecosystem survey across the Eurasian Basin with pelagic trawling to the North Pole.
Paul A. Dodd, Haakon Hop, Anna Nikolopoulos, Mats A. Granskog, Vegard Stürzinger, Anette Wold, Rolf J. Korneliussen, Ole Arve Misund   +7 more
doaj   +1 more source

Resource‐driven colonization by cod in a high Arctic food web

Ecology and Evolution, 2020
Climate change is commonly associated with many species redistributions and the influence of other factors may be marginalized, especially in the rapidly warming Arctic.
Edda Johannesen, Nigel G. Yoccoz, Torkild Tveraa, Nancy L. Shackell, Kari E. Ellingsen, Andrey V. Dolgov, Kenneth T. Frank   +6 more
doaj   +1 more source

Ancient DNA reveals a southern presence of the Northeast Arctic cod during the Holocene. [PDF]

Biol Lett, 2022
Martínez-García L, Ferrari G, Hufthammer AK, Jakobsen KS, Jentoft S, Barrett JH, Star B.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A review of chlorinated paraffin contamination in Arctic ecosystems

Emerging Contaminants, 2019
Chlorinated paraffins (CPs) present a complex mixture of congeners which are often analysed and assessed as short-, medium- and long-chain CPs, i.e. ΣSCCP (C10–C13), ΣMCCP (C14–C17) and ΣLCCP (≥C18).
Katrin Vorkamp, Jennifer Balmer, Hayley Hung, Robert J. Letcher, Frank F. Rigét   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Genomic architecture and population structure of Boreogadus saida from Canadian waters

Scientific Reports
The polar cod, Boreogadus saida, is an abundant and ubiquitous forage fish and a crucial link in Arctic marine trophic dynamics. Our objective was to unravel layers of genomic structure in B.
Trevor T. Bringloe, Audrey Bourret, David Cote, Roux Marie-Julie, Jennifer Herbig, Dominique Robert, Maxime Geoffroy, Geneviève J. Parent   +7 more
doaj   +1 more source