Results 51 to 60 of about 2,466 (257)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Diet of the ringed seal (Phoca hispida) in Greenland

NAMMCO Scientific Publications, 1998
Analysis of 454 stomachs of ringed seals (Phoca hispida) collected from the Inuit hunt in six municipalities in West Greenland and 30 alimentary tracts collected by scientists in East Greenland, showed seasonal and regional differences in the diet.
Helle Siegstad, Pia Barner Neve, Mads Peter Heide-Jørgensen, Tero Härkönen   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Occurrence of sterile North-East Arctic cod individual

Vestnik MGTU, 2018
Based on histological analysis, cod individuals of older age groups that completely lost their reproductive capacity due to age-related gonads' degeneration have been considered. Such individuals have been found among both females and males.
Filina E. A. , Makeenko G. A.
doaj   +1 more source

Polar cod in jeopardy under the retreating Arctic sea ice [PDF]

Communications Biology, 2019
AbstractThe Arctic amplification of global warming is causing the Arctic-Atlantic ice edge to retreat at unprecedented rates. Here we show how variability and change in sea ice cover in the Barents Sea, the largest shelf sea of the Arctic, affect the population dynamics of a keystone species of the ice-associated food web, the polar cod (Boreogadus ...
Mats Brockstedt Olsen Huserbråten, Elena Eriksen, Harald Gjøsæter, Frode Vikebø   +3 more
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mesopelagic Sound Scattering Layers of the High Arctic: Seasonal Variations in Biomass, Species Assemblage, and Trophic Relationships

Frontiers in Marine Science, 2019
Mesopelagic sound scattering layers (SSL) are ubiquitous in all oceans. Pelagic organisms within the SSL play important roles as prey for higher trophic levels and in climate regulation through the biological carbon pump.
Maxime Geoffroy, Maxime Geoffroy, Malin Daase, Marine Cusa, Gérald Darnis, Martin Graeve, Néstor Santana Hernández, Jørgen Berge, Jørgen Berge, Paul E. Renaud, Paul E. Renaud, Finlo Cottier, Finlo Cottier, Stig Falk-Petersen, Stig Falk-Petersen   +14 more
doaj   +1 more source

Stable isotope evidence for late medieval (14th-15th C) origins of the eastern Baltic cod (Gadus morhua) fishery. [PDF]

PLoS ONE, 2011
Although recent historical ecology studies have extended quantitative knowledge of eastern Baltic cod (Gadus morhua) exploitation back as far as the 16th century, the historical origin of the modern fishery remains obscure.
David C Orton, Daniel Makowiecki, Tessa de Roo, Cluny Johnstone, Jennifer Harland, Leif Jonsson, Dirk Heinrich, Inge Bødker Enghoff, Lembi Lõugas, Wim Van Neer, Anton Ervynck, Anne Karin Hufthammer, Colin Amundsen, Andrew K G Jones, Alison Locker, Sheila Hamilton-Dyer, Peter Pope, Brian R MacKenzie, Michael Richards, Tamsin C O'Connell, James H Barrett   +20 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source