Results 71 to 80 of about 2,416 (260)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Resource‐driven colonization by cod in a high Arctic food web
Ecology and Evolution, 2020 Climate change is commonly associated with many species redistributions and the influence of other factors may be marginalized, especially in the rapidly warming Arctic.
Edda Johannesen +6 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Ancient DNA reveals a southern presence of the Northeast Arctic cod during the Holocene. [PDF]
Biol Lett, 2022 Martínez-García L +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
A review of chlorinated paraffin contamination in Arctic ecosystems
Emerging Contaminants, 2019 Chlorinated paraffins (CPs) present a complex mixture of congeners which are often analysed and assessed as short-, medium- and long-chain CPs, i.e. ΣSCCP (C10–C13), ΣMCCP (C14–C17) and ΣLCCP (≥C18).
Katrin Vorkamp +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Genomic architecture and population structure of Boreogadus saida from Canadian waters
Scientific ReportsThe polar cod, Boreogadus saida, is an abundant and ubiquitous forage fish and a crucial link in Arctic marine trophic dynamics. Our objective was to unravel layers of genomic structure in B.
Trevor T. Bringloe +7 more
doaj +1 more source
Ecosystem structure and function of the North Water Polynya
Arctic ScienceThe North Water Polynya is one of the most productive Arctic regions on Earth, sustaining the world's northernmost Inuit communities for millennia. The polynya is a large and persistent region of open water surrounded by sea ice and exhibits high primary
Andrea Bryndum-Buchholz +4 more
doaj +1 more source
BMC Genetics, 2008 Background The Atlantic cod (Gadus morhua) is a groundfish of great economic value in fisheries and an emerging species in aquaculture. Genetic markers are needed to identify wild stocks in order to ensure sustainable management, and for marker-assisted ...
Fjalestad Kjersti T +7 more
doaj +1 more source