Results 91 to 100 of about 37,305 (333)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Carbon and nitrogen assimilation in the Bering Sea clams Nuculana radiata and Macoma moesta [PDF]

, 2012
We analyzed bulk carbon and nitrogen stable isotope values (delta C-13 and delta N-15) of the benthic clams Nuculana radiata and Macoma moesta from the Bering Sea during controlled feeding experiments (spring of 2009 and 2010) using isotopically labeled ...
Gradinger, Rolf, Iken, Katrin, Weems, Jared, Wooller, Matthew   +3 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Ozone depletion events observed in the high latitude surface layer during the TOPSE aircraft program [PDF]

, 2003
During the Tropospheric Ozone Production about the Spring Equinox (TOPSE) aircraft program, ozone depletion events (ODEs) in the high latitude surface layer were investigated using lidar and in situ instruments.
Atlas, EL, Blake, DR, Blake, NJ, Browell, EV, Cantrell, CA, Cinquini, L, Coffey, MT, Cohen, RC, DeYoung, RJ, Dibb, JE, Eisele, FL, Emmons, LK, Flocke, FM, Fried, A, Grahek, FE, Grant, WB, Hair, JW, Hannigan, JW, Heikes, BJ, Lefer, BL, Mauldin, RL, Montzka, DD, Moody, JL, Ridley, BA, Shetter, RE, Snow, JA, Talbot, RW, Thornton, JA, Walega, JG, Weinheimer, AJ, Wert, BP, Wimmers, AJ   +31 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

SEASAT views oceans and sea ice with synthetic aperture radar [PDF]

Fifty-one SEASAT synthetic aperture radar (SAR) images of the oceans and sea ice are presented. Surface and internal waves, the Gulf Stream system and its rings and eddies, the eastern North Pacific, coastal phenomena, bathymetric features, atmospheric ...
Fu, L. L., Holt, B.
core   +1 more source

The International Bathymetric Chart of the Arctic Ocean (IBCAO) Version 3.0 [PDF]

, 2012
[1] The International Bathymetric Chart of the Arctic Ocean (IBCAO) released its first gridded bathymetric compilation in 1999. The IBCAO bathymetric portrayals have since supported a wide range of Arctic science activities, for example, by providing ...
Accettella, Daniela, Anderson, Robert M., Armstrong, Andy, Beinhoff, Paul, Camerlenghi, Angelo, Church, Ian, Coakley, Bernard, Dowdeswell, Julian A., Edwards, Margo, Forbes, Steve, Fridman, Boris, Gardner, James V., Hall, John K., Hell, Benjamin, Hestvik, Ole, Hodnesdal, Hanne, Jakobsson, Martin, Krisoffersen, Yngve, Marcussen, Christian, Mayer, Larry A., Mohammad, Rezwen, Mosher, David, Nghiem, Son V., Noormets, Riko, Pedersen, Richard, Pedrosa, Maria Teresa, Rebesco, Michele, Schenke, Hans Werner, Travaglini, Paola G., Weatherall, Pauline, Zarayskaya, Yulia   +30 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Publisher Correction: Frequent new particle formation over the high Arctic pack ice by enhanced iodine emissions [PDF]

, 2020
Andrea Baccarini, L. Karlsson, Josef Dommen, Patrick Duplessis, Jutta Vüllers, Ian M. Brooks, Alfonso Saiz‐Lopez, Matthew Salter, Michael Tjernström, Urs Baltensperger, Paul Zieger, Julia Schmale   +11 more
openalex   +1 more source