Results 71 to 80 of about 726,424 (281)

Unprecedented Beaufort Sea ice loss in late summer 2021 and its relationship to an extended period of unusually stormy weather

Environmental Research Letters
Previous case studies have linked cyclone-induced atmospheric forcing and/or upper-ocean processes to notable Arctic sea ice loss events in the summers of 2012 and 2016.
Thomas J Ballinger, Peter M Finocchio, Vladimir A Alexeev, Igor V Polyakov, James D Doyle, Matthew G Fearon, Linette Boisvert, Chelsea Parker   +7 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Seasonal and spatial variations in sea ice kinematics and their response to storms in the Arctic Transpolar Drift region in 2021–2022

Journal of Glaciology
Sea ice outflow through the Transpolar Drift (TPD) is essential in Arctic sea ice loss. Twenty-four buoys deployed in the Arctic Ocean during the summer of 2021 were used to analyse sea ice kinematics and deformation across the pack ice zone (PIZ) and ...
Minghao Liu, Ruibo Lei, Long Lin, Jennifer K. Hutchings, Ying Chen, Meng Qu, Xuhua Cheng   +6 more
doaj   +1 more source

Environmental drivers of under-ice phytoplankton bloom dynamics in the Arctic Ocean

Elementa: Science of the Anthropocene, 2020
The decline of sea-ice thickness, area, and volume due to the transition from multi-year to first-year sea ice has improved the under-ice light environment for pelagic Arctic ecosystems.
Mathieu Ardyna, C. J. Mundy, Matthew M. Mills, Laurent Oziel, Pierre-Luc Grondin, Léo Lacour, Gauthier Verin, Gert Van Dijken, Joséphine Ras, Eva Alou-Font, Marcel Babin, Michel Gosselin, Jean-Éric Tremblay, Patrick Raimbault, Philipp Assmy, Marcel Nicolaus, Hervé Claustre, Kevin R. Arrigo   +17 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Recent trends in melting conditions on the Antarctic Peninsula and their implications for ice-sheet mass balance and sea level [PDF]

, 2006
Long-term records from meteorological stations on the Antarctic Peninsula show strong rising trends in the annual duration of melting conditions. In each case, the trend is statistically significant and represents a major increase in the potential for ...
Dowdeswell, J.A., Bassford, R. P., Glazovsky, A.F., Glazovsky, A. F., Siegert, M. J,, Macheret, Y.Y., Macheret, Y. Y., Vaughan, David G., J. A. Dowdeswell, David G. Vaughan, A. F. Glazovsky, Oerlemans, J., R. P. Bassford, Bassford, R.P., Y. Y. Macheret, M. J. Siegert, Siegert, M. J., Dowdeswell, J. A., Siegert, M.J., J. Oerlemans, Hoch, Günter, Dowling, Carolyn, Vaughn, Bruce H., Olofsson, Johan,, Körner, Christian, Lyons, W. Berry, Gooseff, Michael N., Fountain, Andrew G., McKnight, Diane M.   +28 more
core   +2 more sources

Drivers of Changing Interannual Variability in Autumn‐Early Winter Arctic Sea Ice (1950–2024)

Geophysical Research Letters
Arctic sea ice has undergone a pronounced decline over recent decades, yet the drivers of its interannual variability remains unclear. Here we utilize standard deviation to assess long‐term changes in autumn‐early winter (October–December) Arctic sea ice
Lejiang Yu, Shiyuan Zhong, Timo Vihma
doaj   +1 more source

Hypotheses and tracking results about the longest migration: The case of the arctic tern

Ecology and Evolution, 2019
The arctic tern Sterna paradisaea completes the longest known annual return migration on Earth, traveling between breeding sites in the northern arctic and temperate regions and survival/molt areas in the Antarctic pack‐ice zone.
Thomas Alerstam, Johan Bäckman, Johanna Grönroos, Patrik Olofsson, Roine Strandberg   +4 more
doaj   +1 more source

Studies of the Mass Budget of Arctic Pack-Ice Floes [PDF]

Journal of Glaciology, 1965
AbstractThe processes of melting, freezing, precipitation, evaporation and condensation were considered in the computation of the mass budget of an ice floe in the northern Chukchi Sea. It was bound that condensation and evaporation contribute negligible amounts, and that melting accounted for the largest loss from the upper surface of the floe.
openaire   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source