Results 61 to 70 of about 726,424 (281)
Remote Sensing, 2023 Accurate retrieval of ice surface temperature (IST) over the Arctic ice-water mixture zone (IWMZ) is significantly essential for monitoring the change of the polar sea ice environment.
Lijuan Song +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
ARCTlC Winter Sightings of Marine Mammals in Arctic Pack Ice [PDF]
, 1987 . There is limited information about the winter distribution of some arctic marine mmals. In February-March 1976 six species of marine mammals were sighted in the pack ice of Baffin Bay and Davis Strait.
Charles W. Turl, Turl, Charles W.
core
Scientific Reports, 2023 As a result of global warming, the area of the polar pack ice is diminishing, making merchant travel more practical. Even if Arctic ice thickness reduced in the summer, fractured ice is still presenting operational risks to the future navigation.
Oleg Gaidai +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Automatic detection of Arctic polynyas using hybrid supervised-unsupervised deep learning [PDF]
The CryospherePolynyas are open water or thin-ice areas within the ice pack. They play a crucial role for the Earth system, from deep water to cloud formation, causing large gas exchanges, and acting as hotspots for marine life.
C. Heuzé, C. H. M. Wong
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
CLIMATE CHANGE AT HIGH LATITUDES: AN ILLUMINATING EXAMPLE
Zygon, 2018 A striking example is presented of a newly observed phenomenon in the ice‐covered Arctic Ocean that appears to be a consequence of changes in the physical forcing.
doaj +2 more sources
Culturable diversity of Arctic phytoplankton during pack ice melting [PDF]
Elementa: Science of the Anthropocene, 2019 Massive phytoplankton blooms develop at the Arctic ice edge, sometimes extending far under the pack ice. An extensive culturing effort was conducted before and during a phytoplankton bloom in Baffin Bay between April and July 2016. Different isolation strategies were applied, including flow cytometry cell sorting, manual single cell pipetting, and ...
Ribeiro, Catherine Gérikas +7 more
openaire +4 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source