Results 41 to 50 of about 2,485 (283)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Frontiers in Earth Science, 2018 An ice watch, encompassing visual observation of sea ice conducted from the ship's bridge, is typically performed on sea-ice oriented research cruises.
Jennifer K. Hutchings, M. Kate Faber
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Winter sea ice export from the Laptev Sea preconditions the local summer sea ice cover and fast ice decay [PDF]
The Cryosphere, 2017 Ice retreat in the eastern Eurasian Arctic is a consequence of atmospheric and oceanic processes and regional feedback mechanisms acting on the ice cover, both in winter and summer.
P. Itkin, P. Itkin, T. Krumpen
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Meteorological and sea ice anomalies in the western Arctic Ocean during the 2018–2019 ice season: a Lagrangian study [PDF]
, 2022 Rapid changes in the Arctic climate and those in Arctic sea ice in recent decades are closely coupled. In this study, we used atmospheric reanalysis data and satellite remote sensing products to identify anomalies of meteorological and sea ice conditions
Mengxi, Zhai, Ruibo, Lei, Fanyi, Zhang
core +1 more source
Transition in the fractal geometry of Arctic melt ponds [PDF]
The Cryosphere, 2012 During the Arctic melt season, the sea ice surface undergoes a remarkable transformation from vast expanses of snow covered ice to complex mosaics of ice and melt ponds.
C. Hohenegger +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The summer aerosol in the central Arctic 1991–2008: did it change or not? [PDF]
Atmospheric Chemistry and Physics, 2012 In the course of global warming dramatic changes are taking place in the Arctic and boreal environments. However, physical aerosol data in from the central summer Arctic taken over the course of 18 yr from 1991 to 2008 do not show systematic year-to-year
J. Heintzenberg, C. Leck
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source