Results 231 to 240 of about 37,291 (294)

Monitoring climate change impacts, Indigenous livelihoods and adaptation: Perspectives from Inuit community of Hopedale, Nunatsiavut, Canada. [PDF]

Camb Prism Coast Futur
Malik IH, Ford JD, Winters I, Hunter B, Flowers N, Quincey D, Flowers K, Flowers M, Coombs D, Foltz-Vincent C, Barrand NE, Way RG.   +11 more
europepmc   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Microbiome and Microbial Profiling of Arctic Snow Using Whole Genome Sequencing, Psychrophilic Culturing, and Novel Sampling Techniques. [PDF]

J Biomol Tech
Tighe SW, Vellone DL, Tracy KM, Lynch DB, Finstad KH, Mcllelan MC, Dragon JA.   +6 more
europepmc   +1 more source

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Iodine speciation in snow during the MOSAiC expedition and its implications for Arctic iodine emissions.

Faraday Discuss
Brown LV, Pound RJ, Jones MR, Rowlinson MJ, Chance R, Jacobi HW, Frey MM, Archer SD, Arndt S, Barten JGM, Blomquist BW, Dadic R, Ganzeveld LN, Hannula HR, Helmig D, Jaggi M, Krampe D, Macfarlane AR, Miller S, Schneebeli M, Carpenter LJ.   +20 more
europepmc   +1 more source

Landscape heterogeneity buffers the impact of an extreme weather event on wildlife. [PDF]

Commun Biol
Prugh LR, Lundquist JD, Sullender BK, Cunningham CX, Dechow J, Borg BL, Sousanes PJ, Stehn S, Durand MT.   +8 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Non-linear frequency doubling up-conversion of geothermal radiation cannot provide sufficient light to support oxygenic photosynthesis at deep-sea hydrothermal vents. [PDF]

Natl Sci Rev
Mullineaux CW, Duffy CDP.
europepmc   +1 more source

Towards a European Research Icebreaker and Deep Sea Drilling Facility for Polar Research: ERICON-AURORA BOREALIS [PDF]

, 2011
Azzolini, R., Biebow, Nicole, Lembke-Jene, Lester, Thiede, Jörn, Willmott, Veronica, Wolff-Boenisch, Bonnie   +5 more
core  

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source