Results 231 to 240 of about 2,485 (283)

Temporal dynamics and biogeography of sympagic and planktonic photosynthetic microbial eukaryotes during the under-ice Arctic bloom. [PDF]

ISME Commun
Sim CWH, Ribeiro CG, Le Gall F, Probert I, Gourvil P, Lovejoy C, Vaulot D, Lopes Dos Santos A.   +7 more
europepmc   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Amazon in the Arctic: E-Commerce, Infrastructure, and Alimentary Assemblages in Nunavut, Canada. [PDF]

J Contemp Ethnogr
Schmid K.
europepmc   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Spatiotemporal patterns and implications of suspended <i>Alexandrium catenella</i> cysts in the Pacific Arctic region. [PDF]

Deep Sea Res 2 Top Stud Oceanogr
Fachon E, Pickart RS, Huang J, Lalande C, Anderson DM.   +4 more
europepmc   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

East Siberian ice wedges recording dust transport variability during the Late Pleistocene. [PDF]

Nat Commun
Kim S, Lee H, Kim J, Lee Y, Choi JH, Lee MJ, Kwon UJ, Iwahana G, Opel T, Meyer H, Wetterich S, Fedorov A, Ahn J.   +12 more
europepmc   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Behavioural analysis of multi-year satellite telemetry data provides insight into narwhal (Monodon monoceros) winter prey selection in Baffin Bay. [PDF]

PLoS One
Hornby CA, Togunov RR, McClintock BT, Watt CA.   +3 more
europepmc   +1 more source

Sensitivity to airborne sounds in ice-dependent bearded seals. [PDF]

J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Packard N, Sills JM, Jones RA, Aldana ST, Reichmuth C.   +4 more
europepmc   +1 more source