Results 231 to 240 of about 726,424 (281)

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Narwhal acoustic presence in Eclipse Sound, Nunavut: relationships with sea ice and responses to ships. [PDF]

Sci Rep
Ewing JP, Hidalgo-Pla E, Solsona-Berga A, Frasier KE, Ootoowak AJ, Westdal KH, Wiggins SM, Hildebrand JA, Jones JM.   +8 more
europepmc   +1 more source

Substrate Engineering of SWCNT p–n Junctions for Dual‐Mode Power Generation and Heat‐Flux Sensing

Advanced Science, EarlyView.
Through substrate engineering alone, a single‐walled carbon nanotube p–n junction device switches between two functions under uniform infrared irradiation. A low‐absorbance substrate sustains a central hot junction for continuous power generation, whereas high‐absorbance substrates transiently invert the temperature gradient for sensitive heat‐flux ...
Ryota Tamai, Hiroto Nakayama, Shuya Ochiai, Masayuki Takashiri   +3 more
wiley   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Projecting the future of a threatened marine mammal in relation to climate warming. [PDF]

Ecol Appl
Regehr EV, Quakenbush L, Von Duyke AL, Citta JJ, Lindsay JM.   +4 more
europepmc   +1 more source

A comprehensive characterisation of natural aerosol sources in the high Arctic during the onset of sea ice melt.

Faraday Discuss
Freitas GP, Kojoj J, Mavis C, Creamean J, Mattsson F, Nilsson L, Schmidt JS, Adachi K, Šantl-Temkiv T, Ahlberg E, Mohr C, Riipinen I, Zieger P.   +12 more
europepmc   +1 more source

Intracellular nutrient storage during ice algal spring blooms in the Canadian high Arctic. [PDF]

iScience
Mundy CJ, Leu E, Campbell K, Galindo V, Levasseur M, Poulin M, Tremblay JÉ, Gosselin M.   +7 more
europepmc   +1 more source

Temporal dynamics and biogeography of sympagic and planktonic photosynthetic microbial eukaryotes during the under-ice Arctic bloom. [PDF]

ISME Commun
Sim CWH, Ribeiro CG, Le Gall F, Probert I, Gourvil P, Lovejoy C, Vaulot D, Lopes Dos Santos A.   +7 more
europepmc   +1 more source

Amazon in the Arctic: E-Commerce, Infrastructure, and Alimentary Assemblages in Nunavut, Canada. [PDF]

J Contemp Ethnogr
Schmid K.
europepmc   +1 more source