Results 251 to 260 of about 57,296 (333)

MEA‐seqX: High‐Resolution Profiling of Large‐Scale Electrophysiological and Transcriptional Network Dynamics

Advanced Science, EarlyView.
How can we fully understand brain function and disease without uncovering the causal coordination between molecular and neural activity across space and time? MEA‐seqX tackles this challenge by integrating advanced electrophysiology, spatial transcriptomics, and artificial intelligence predictions, revealing multiscale dynamics.
Brett Addison Emery, Xin Hu, Diana Klütsch, Shahrukh Khanzada, Ludvig Larsson, Ionut Dumitru, Jonas Frisén, Joakim Lundeberg, Gerd Kempermann, Hayder Amin   +9 more
wiley   +1 more source

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

Redefining Arctic boundaries in a changing climate: interdisciplinary perspectives on governance strategies. [PDF]

Polar Geogr (Palm Beach)
Nanni U, DeRepentigny P, Lundén A, Popovaitė V, Shen Y, Basaran IK, Duarte Neubern N, Mascorda-Cabre L, Bennett A, Vold Hansen T, Holmes FA, Kavvatha E, Meyer A, Prakash A, Wołoszyn A.   +14 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Seafloor primary production in a changing Arctic Ocean. [PDF]

Proc Natl Acad Sci U S A
Attard K, Singh RK, Gattuso JP, Filbee-Dexter K, Krause-Jensen D, Kühl M, Sejr MK, Archambault P, Babin M, Bélanger S, Berg P, Glud RN, Hancke K, Jänicke S, Qin J, Rysgaard S, Sørensen EB, Tachon F, Wenzhöfer F, Ardyna M.   +19 more
europepmc   +1 more source

Sea ice diffusion in the Arctic ice pack: a comparison between observed buoy trajectories and the neXtSIM and TOPAZ-CICE sea ice models

, 2016
Pierre Rampal, Sylvai Bouillon, Jon Bergh, Einar Ólason   +3 more
openalex   +1 more source

Construction of Protein‐Like Helical‐Entangled Structure in Lithium‐Ion Silicon Anode Binders via Helical Recombination and Hofmeister Effect

Advanced Science, EarlyView.
This study presents a gelatin‐xanthan gum composite binder featuring a protein‐like helical‐entangled structure, formed through thermo‐responsive recombination and the Hofmeister effect. This innovative structure, akin to protein behavior, absorbs stress and strain, thereby enhancing the cycling stability and rate performance of silicon anodes in ...
Shiyuan Dai, Fei Huang, Jinglun Yan, Yuan Yuan Sun, Chao Chen, HaiDong Li   +5 more
wiley   +1 more source

Polar bears and expanding sea ice in the Mid Holocene Aleutian Islands, Alaska. [PDF]

Sci Rep
Parker LD, West CF, Tatum KH, Etnier M, Bethke B, Reedy K, Shellikoff N, Hofman CA.   +7 more
europepmc   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

An Assessment of Subseasonal Prediction Skill of the Antarctic Sea Ice Edge. [PDF]

J Geophys Res Oceans
Gao Y, Xiu Y, Nie Y, Luo H, Yang Q, Zampieri L, Lv X, Uotila P.   +7 more
europepmc   +1 more source