Results 81 to 90 of about 37,305 (333)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Unprecedented Beaufort Sea ice loss in late summer 2021 and its relationship to an extended period of unusually stormy weather

Environmental Research Letters
Previous case studies have linked cyclone-induced atmospheric forcing and/or upper-ocean processes to notable Arctic sea ice loss events in the summers of 2012 and 2016.
Thomas J Ballinger, Peter M Finocchio, Vladimir A Alexeev, Igor V Polyakov, James D Doyle, Matthew G Fearon, Linette Boisvert, Chelsea Parker   +7 more
doaj   +1 more source

Seasonal and spatial variations in sea ice kinematics and their response to storms in the Arctic Transpolar Drift region in 2021–2022

Journal of Glaciology
Sea ice outflow through the Transpolar Drift (TPD) is essential in Arctic sea ice loss. Twenty-four buoys deployed in the Arctic Ocean during the summer of 2021 were used to analyse sea ice kinematics and deformation across the pack ice zone (PIZ) and ...
Minghao Liu, Ruibo Lei, Long Lin, Jennifer K. Hutchings, Ying Chen, Meng Qu, Xuhua Cheng   +6 more
doaj   +1 more source

Beryllium 7 and Lead 210 in the western hemisphere Arctic atmosphere: Observations from three recent aircraft-based sampling programs [PDF]

, 1992
Concentrations of the natural radionuclides 7Be and 210Pb were determined in aerosol samples collected in the western hemisphere Arctic during the recent NOAA Arctic Gas and Aerosol Sampling Program (AGASP 3) and NASA Global Tropospheric Experiment ...
Dibb, Jack E., Gregory, G L, Talbot, R.
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Hypotheses and tracking results about the longest migration: The case of the arctic tern

Ecology and Evolution, 2019
The arctic tern Sterna paradisaea completes the longest known annual return migration on Earth, traveling between breeding sites in the northern arctic and temperate regions and survival/molt areas in the Antarctic pack‐ice zone.
Thomas Alerstam, Johan Bäckman, Johanna Grönroos, Patrik Olofsson, Roine Strandberg   +4 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Shipping Through Sea Ice: Impacts on Marine Habitats and Best Practices [PDF]

, 2017
As the result of Arctic climate change and an increase in shipping season length, there is a growing interest in Arctic shipping operations. Sea ice serves as an important habitat for marine mammals, therefore, shipping through sea ice could lead to ...

core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Best Laid Schemes: A Nares Strait Adventure [PDF]

Oceanography, 2011
In 2002, oceanographers began a study of Arctic freshwater export via Nares Strait (Münchow et al., 2006). This 550 km channel separating Greenland from Canada is possibly the longest narrow waterway on Earth.
Humfrey Melling
doaj