Results 91 to 100 of about 226,222 (357)

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Seasonal variation of the transport of black carbon aerosol from the Asian continent to the Arctic during the ARCTAS aircraft campaign [PDF]

, 2011
Extensive measurements of black carbon (BC) aerosol were conducted in and near the North American Arctic during the Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) aircraft campaign in April and June-July 2008.
Blake, DR, Diskin, G, Fuelberg, HE, Koike, M, Kondo, Y, Matsui, H, Moteki, N, Sahu, LK, Sessions, WR, Takegawa, N, Wisthaler, A, Zhao, Y   +11 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Transition from traditional cars to electric ones in Arctic regions [PDF]

E3S Web of Conferences
The study analyses the prospects for the transition from traditional vehicles running on gasoline and diesel fuel to more environmentally friendly types of vehicles (electric) in the northern and arctic northern and arctic regions.
Shvetsov Alexey
doaj   +1 more source

Effect of solar activity on the frequency of occurrence of major anomalies in the Arctic [PDF]

Major air pressure and temperature anomalies in certain arctic regions were studied with a view toward predicting their occurrence. Correlations are sought between the frequency of arctic anomalies and solar activity, or specifically the Wolf number and ...
Bolotinskaya, M. S.
core   +1 more source

Algebraic arctic curves in the domain-wall six-vertex model

, 2010
The arctic curve, i.e. the spatial curve separating ordered (or `frozen') and disordered (or `temperate) regions, of the six-vertex model with domain wall boundary conditions is discussed for the root-of-unity vertex weights.
A G Pronko, Allison D, Cohn H, Colomo F, Colomo F, F Colomo, Izergin A G, Izergin A G, Jockush W Propp J Shor P, Korepin V E, Reshetikhin N, V Noferini, Zinn-Justin P   +12 more
core   +1 more source

Governance of expedition cruise ship tourism in the arctic: A comparison of the Canadian and Russian Arctic [PDF]

, 2015
Expedition style cruise tourism represents a significant proportion of shipping activity across the Arctic. This article compares and contrasts governance structures that manage the cruise sector from case studies located in the Canadian (Nunavut) and ...
Dawson, J, Pashkevich, A, Stewart, Emma
core   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Patterns of CO2 and radiocarbon across high northern latitudes during International Polar Year 2008 [PDF]

, 2011
High-resolution in situ CO2 measurements were conducted aboard the NASA DC-8 aircraft during the ARCTAS/POLARCAT field campaign, a component of the wider 2007-2008 International Polar Year activities.
Blake, DR, Burkhart, JF, Choi, Y, Diskin, GS, Hecobian, A, Kondo, Y, Sachse, GW, Stohl, A, Tyler, SC, Vadrevu, KP, Vay, SA, Weinheimer, AJ, Wennberg, PO, Wisthaler, A, Woo, JH   +14 more
core   +1 more source