Results 101 to 110 of about 3,061,171 (419)

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source

Fluctuations and arctic curve in the Aztec diamond [PDF]

arXiv, 2023
Domino tilings of Aztec diamonds are known to exhibit an arctic phenomenon, namely a separation between frozen regions (in which all the dominoes have the same orientation) and a central disordered region (where dominoes are found without any apparent order). This separation was proved to converge, under a suitable rescaling, to the Airy process whose $
arxiv  

MODERN APPROACH TO ARTERIAL HYPERTENSION IN THE CIRCUMPOLAR AND ARCTIC REGIONS. LITERATURE REVIEW

, 2016
A new approach to the problem of significant youthification of arterial hypertension and its fast progression in non-indigenous populations of the polar and arctic regions has been presented.
V. I. Hasnulin, Хаснулин Павел Вячеславович, M. Voevoda, И ВоеводаМ, P. V. Hasnulin, В ХаснулинП, O. G. Artamonova, Г АртамоноваО   +7 more
semanticscholar   +1 more source

Human potential as a strategic resource of the Russian Arctic sustainable development [PDF]

, 2016
Efficiency of the Russian Arctic development depends greatly on human potential of the population inhabiting and conducting work activities in the Arctic regions.
Bolsunovskaya, Yuliya Aleksandrovna, Sentsov, A.   +1 more
core   +2 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Accounting of the internal structure of the ice hummock keel in thermodynamic calculations of the evolution of the consolidated layer

Лëд и снег, 2020
Materials from long-term field observations of the internal structure of ice hummocks in the Arctic seas were analyzed. Empirical expressions describing the porosity distribution of the underwater part of a newly-formed hummock depending on the depth and
O. M. Andreev
doaj   +1 more source

A stochastic model for the turbulent ocean heat flux under Arctic sea ice [PDF]

arXiv, 2021
The physics of planetary climate features a variety of complex systems that are challenging to model as they feature turbulent flows. A key example is the heat flux from the upper ocean to the underside of sea ice which provides a key contribution to the evolution of the Arctic sea ice cover.
arxiv  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source