Results 61 to 70 of about 33,196 (315)

STRUCTURAL SHIFTS IN THE ARCTIC ECONOMY DRIVEN BY THE SPILLOVER OF INVESTMENT DEMAND ACROSS INDUSTRIES

Север и рынок: формирование экономического порядка
Under financial constraints, the formulation of structural and investment policies in the Arctic regions must account for investment flows between industries. This highlights the importance of analyzing structural shifts within economic systems resulting
Vladimir N. Myakshin, Vladimir N. Petrov, Lyudmila A. Chizhova, Tatyana N. Pesyakova   +3 more
doaj   +1 more source

Directions and Priorities for Tourism Development in the Arctic: Content Analysis of Strategic Documents

Арктика и Север
The number of strategic documents has been adopted at the federal level in recent years, establishing the regulatory regime for the development of tourism in the Arctic.
Svetlana V. Kondrateva , Ekaterina A. Shlapeko   +1 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Transition from traditional cars to electric ones in Arctic regions [PDF]

E3S Web of Conferences
The study analyses the prospects for the transition from traditional vehicles running on gasoline and diesel fuel to more environmentally friendly types of vehicles (electric) in the northern and arctic northern and arctic regions.
Shvetsov Alexey
doaj   +1 more source

The second year of pandemic in the Arctic: examining spatiotemporal dynamics of the COVID-19 "Delta wave" in Arctic regions in 2021. [PDF]

Int J Circumpolar Health, 2022
Tiwari S, Petrov AN, Devlin M, Welford M, Golosov N, DeGroote J, Degai T, Ksenofontov S.   +7 more
europepmc   +1 more source

Metal mining impacts on social ecological systems in boreal and Arctic regions.

, 2021
Neal Haddaway
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Seasonal variations in physical activity among Norwegian elementary school children in Arctic regions. [PDF]

Int J Circumpolar Health, 2021
Danielsen KH, Vårnes TK, Sagelv EH, Heitmann KA, Mathisen GE.   +4 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source