Results 61 to 70 of about 232,498 (309)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Digitalization in Education and Distance Barriers in the Russian Arctic: Problems and Prospects

Арктика и Север, 2021
In the era of digital technologies, the issues of providing highly qualified personnel, the effective use of the intellectual potential of the territory and the creation of conditions for its reproduction are of particular importance.
Natalya V. DYADIK, Anastasiya N. CHAPARGINA   +1 more
doaj   +1 more source

A Tropospheric Assessment of the ERA-40, NCEP, and JRA-25 Global Reanalyses in the Polar Regions [PDF]

, 2007
The reliability of the global reanalyses in the polar regions is investigated. The overview stems from an April 2006 Scientific Committee on Antarctic Research (SCAR) workshop on the performance of global reanalyses in high latitudes held at the British ...
Adler, Andersson, Baldwin, Bengtsson, Bengtsson, Bengtsson, Bromwich, Bromwich, Bromwich, Bromwich, Bromwich, Crochet, Cullather, David H. Bromwich, Déry, Fogt, Francis, Gong, Hanna, Hines, Hodges, Hodges, Hoskins, Hoskins, Ishii, John E. Walsh, Kalnay, Kanamitsu, Kevin I. Hodges, Kidson, Kistler, L'Heureux, Marshall, Marshall, Marshall, Monaghan, Onogi, Raphael, Renwick, Richman, Ryan L. Fogt, Schubert, Serreze, Serreze, Serreze, Serreze, Serreze, Serreze, Serreze, Serreze, Sterl, Sturaro, Su, Tennant, Thompson, Trenberth, Trenberth, Turner, Uppala, van de Berg, van de Berg, Vaughan, Walsh, Wang   +63 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Sound absorption in Arctic regions [PDF]

The Journal of the Acoustical Society of America, 1987
Sound absorption in seawater involves relaxations of magnesium sulfate, boric acid, and magnesium carbonate. Absorption varies with both region and depth, due mainly to the pH dependence of the boric acid relaxation. The nominal seawater pH range is 7.7–8.3 and magnitudes can vary over nearly a factor of 4 at low frequencies.
R. H. Mellen, P. S. Scheifele, D. G. Browning   +2 more
openaire   +1 more source

Significant parameters of mining properties in arctic and subarctic areas of North America [PDF]

, 1983
Editors: Bruce W. Campbell and John J. DiMarchiThis paper is a review of those factors unique to mining in the Arctic and subarctic. The information was developed from an exhaustive Literature search and personal visits to several northern mines in ...
Hackney, D.A., Lambert, C.
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Comparing Arctic Regional Climate Model [PDF]

Eos, Transactions American Geophysical Union, 2002
Recent climate modeling results show the Arctic to be a region of particular importance and vulnerability to global climate change. Despite the climatic significance of the Arctic, many physical processes occurring in this region are still not well understood.
J. A. Curry, A. H. Lynch
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Masters Students' Perceptions of Distance and Transport Options

Education in the North, 2018
This article is situated within the Arctic Regions North Norway and North/East Iceland. It presents a study on what motivates adults in Arctic regions to apply for and complete a Master’s degree in Education.
Mirjam Harkestad Olsen, Hermína Gunnþórsdóttir   +1 more
doaj   +1 more source