Results 61 to 70 of about 226,222 (357)

A Tropospheric Assessment of the ERA-40, NCEP, and JRA-25 Global Reanalyses in the Polar Regions [PDF]

, 2007
The reliability of the global reanalyses in the polar regions is investigated. The overview stems from an April 2006 Scientific Committee on Antarctic Research (SCAR) workshop on the performance of global reanalyses in high latitudes held at the British ...
Adler, Andersson, Baldwin, Bengtsson, Bengtsson, Bengtsson, Bromwich, Bromwich, Bromwich, Bromwich, Bromwich, Crochet, Cullather, David H. Bromwich, Déry, Fogt, Francis, Gong, Hanna, Hines, Hodges, Hodges, Hoskins, Hoskins, Ishii, John E. Walsh, Kalnay, Kanamitsu, Kevin I. Hodges, Kidson, Kistler, L'Heureux, Marshall, Marshall, Marshall, Monaghan, Onogi, Raphael, Renwick, Richman, Ryan L. Fogt, Schubert, Serreze, Serreze, Serreze, Serreze, Serreze, Serreze, Serreze, Serreze, Sterl, Sturaro, Su, Tennant, Thompson, Trenberth, Trenberth, Turner, Uppala, van de Berg, van de Berg, Vaughan, Walsh, Wang   +63 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Digitalization in Education and Distance Barriers in the Russian Arctic: Problems and Prospects

Арктика и Север, 2021
In the era of digital technologies, the issues of providing highly qualified personnel, the effective use of the intellectual potential of the territory and the creation of conditions for its reproduction are of particular importance.
Natalya V. DYADIK, Anastasiya N. CHAPARGINA   +1 more
doaj   +1 more source

Saline Conversion and Ice Structures from Artificially Grown Sea Ice [PDF]

, 1967
The environment of cold regions is generally viewed as inhospitable, primarily due to application of ideal processes and techniques suitable to temperate zones. The work herein is a step toward solving two environmental problems.
Behlke, C. E., Johnson, P. R., Peyton, H. R.   +2 more
core  

Arctic tree rings as recorders of variations in light availability [PDF]

, 2014
Annual growth ring variations in Arctic trees are often used to reconstruct surface temperature. In general, however, the growth of Arctic vegetation is limited both by temperature and light availability, suggesting that variations in atmospheric ...
Huybers, P., Stine, A. R.
core   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Directions and Priorities for Tourism Development in the Arctic: Content Analysis of Strategic Documents

Арктика и Север
The number of strategic documents has been adopted at the federal level in recent years, establishing the regulatory regime for the development of tourism in the Arctic.
Svetlana V. Kondrateva , Ekaterina A. Shlapeko   +1 more
doaj   +1 more source

Day Auroras in the Arctic Regions [PDF]

Nature, 1871
I CAN now answer Dr. Burder's question regarding the appearance of the Aurora Borealis in the Arctic Regions. The other evening (last Thursday) I had a conversation with a distinguished magnetician and Arctic explorer, and he informed me that he has often seen the Aurora in broad daylight in those regions, the colour invariably being crimson.
openaire   +2 more sources