Results 81 to 90 of about 232,498 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

STRUCTURAL SHIFTS IN THE ARCTIC ECONOMY DRIVEN BY THE SPILLOVER OF INVESTMENT DEMAND ACROSS INDUSTRIES

Север и рынок: формирование экономического порядка
Under financial constraints, the formulation of structural and investment policies in the Arctic regions must account for investment flows between industries. This highlights the importance of analyzing structural shifts within economic systems resulting
Vladimir N. Myakshin, Vladimir N. Petrov, Lyudmila A. Chizhova, Tatyana N. Pesyakova   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

THE RADIO WAVES PROPAGATION CHARACTERISTICS IN THE GLIDESLOPE AXES OF THE GROUND CONTROLLED APPROACH SYSTEMS IN THE ARCTIC REGIONS

Научный вестник МГТУ ГА, 2016
Information about the location of the aircraft, with a decrease along a predetermined path, the carriages, the floor-fer with the use of radio landing systems.
G. S. Nakhmanson, D. V. Buchnev, A. V. Bunin   +2 more
doaj  

Implementation and Effectiveness of Antiretroviral Therapy in Greenland

Emerging Infectious Diseases, 2008
Analyses from the Danish HIV Cohort Study showed that, despite comparable economic means and general education of healthcare personnel, antiretroviral treatment of HIV in Greenland began later and has been implemented at a slower pace with lower ...
Nicolai Lohse, Karin Ladefoged, Niels Obel   +2 more
doaj   +1 more source

Effect of solar activity on the frequency of occurrence of major anomalies in the Arctic [PDF]

Major air pressure and temperature anomalies in certain arctic regions were studied with a view toward predicting their occurrence. Correlations are sought between the frequency of arctic anomalies and solar activity, or specifically the Wolf number and ...
Bolotinskaya, M. S.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

DIGITALIZATION AS A TOOL FOR MANAGING INNOVATION-DRIVEN SUSTAINABLE DEVELOPMENT IN THE ARCTIC INDUSTRIAL SECTOR

Север и рынок: формирование экономического порядка
The sustainable development of industrial production is particularly critical in the Arctic regions. However, achieving this goal requires effective management, which can be improved through digitalization based on algorithmic processes.
Vladimir S. Zharov
doaj   +1 more source

Directions and Priorities for Tourism Development in the Arctic: Content Analysis of Strategic Documents

Арктика и Север
The number of strategic documents has been adopted at the federal level in recent years, establishing the regulatory regime for the development of tourism in the Arctic.
Svetlana V. Kondrateva , Ekaterina A. Shlapeko   +1 more
doaj   +1 more source

Foxes and food subsidies: anthropogenic food use by red and Arctic foxes, and effects on Arctic fox survival, on the Arctic Coastal Plain of Alaska [PDF]

, 2013
Thesis (M.S.) University of Alaska Fairbanks, 2013Food subsidies have the potential to impact wildlife on the Arctic Coastal Plain of Alaska. Red foxes (Vulpes vulpes (L., 1758)) expanded their range into Arctic regions during the 20th century, and the ...
Savory, Garrett
core