Results 81 to 90 of about 33,196 (315)

Migration Attitudes of the Students Enrolled in Arctic-Focused Higher Education Programs

Economic and Social Changes: Facts, Trends, Forecast, 2018
The article presents the findings of a sociological survey conducted in the regions that are partially or completely included in the Arctic zone of the Russian Federation (hereinafter – the Russian Arctic).
Zaikov Konstantin S., Katorin Igor’ V., Tamitskii Aleksandr M.   +2 more
doaj   +1 more source

Prevalence of the polymorphic H-f icolin (FCN3) genes and mannose-binding lectin-associated serine protease-2 (MASP2) in indigenous populations from the Russian Arctic regions. [PDF]

Vavilovskii Zhurnal Genet Selektsii, 2021
Smolnikova MV, Tereshchenko SY.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Professional Self-Determination of Schoolchildren in Years 8–10 of Arctic and Russian Far East Regions: Sociological Analysis

Социологическая наука и социальная практика, 2019
The article deals with the features of professional self-determination of schoolchildren in years 8–10 of Arctic and Russian Far East regions. The study revealed factors that influence the choice of future professions by schoolchildren; generalized ...
Anna V. Simakova
doaj   +1 more source

THE SPECIFICS OF THE SOCIO-ECONOMIC DEVELOPMENT OF THE REGIONS OF THE ARCTIC ZONE OF THE RUSSIAN FEDERATION

, 2023
Artur Alexandrovich Blagorodov, Olga Ivanovna Okhrimenko, Maria Lvovna Vilisova, Владимир Тимофеевич Прохоров, Galina Yurievna Volkova   +4 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The impact of the national Arctic policy on the socio-economic transformations of Russia’s polar regions.

, 2022
Tatiana Skufina, С. В. Баранов, Vera Samarina, Aleksandr Samarin   +3 more
openalex   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Transport System of Northern and Arctic Regions: Assessment and Development Problems

, 2021
В. А. Цукерман, E. S. Goryachevskaya   +1 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source