Results 151 to 160 of about 162,083 (309)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Bathymetry-constrained ocean geostrophic currents play a key role in shaping the sea ice circulation in the Canada Basin, Arctic Ocean

Environmental Research Letters
Satellite-based observations and a pan-Arctic coupled sea ice-ocean model are utilized to study the effect of ocean geostrophic currents on large-scale sea ice circulation in the Canada Basin, Arctic Ocean.
Hengling Leng, Hailun He, Dake Chen, Peigen Lin, Yang Yang, Zhaomin Wang   +5 more
doaj   +1 more source

Evaluation and Decision-Making Optimization of Arctic Navigation Meteorological and Sea Ice Information Websites

Journal of Marine Science and Engineering
The continuous improvement in the seaworthiness of Arctic shipping routes has caused an urgent international demand for meteorological and sea ice information.
Tsung-Hsuan Hsieh, Qian Meng, Bing Han, Shengzheng Wang, Wei Liu   +4 more
doaj   +1 more source

Unprecedented decline of Arctic sea ice outflow in 2018. [PDF]

Nat Commun, 2022
Sumata H, de Steur L, Gerland S, Divine DV, Pavlova O.   +4 more
europepmc   +1 more source

Arctic sea ice change

IOP Conference Series: Earth and Environmental Science, 2009
Son Nehiem, G Neumann
openaire   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Assimilating Summer Sea‐Ice Thickness Observations Improves Arctic Sea‐Ice Forecast

Geophysical Research Letters
Accurate Arctic sea‐ice forecasting for the melt season is still a major challenge because of the lack of reliable pan‐Arctic summer sea‐ice thickness (SIT) data.
Ruizhe Song, Longjiang Mu, Svetlana N. Loza, Frank Kauker, Xianyao Chen   +4 more
doaj   +1 more source

A Winter-to-Summer Transition of Bacterial and Archaeal Communities in Arctic Sea Ice. [PDF]

Microorganisms, 2022
Thiele S, Storesund JE, Fernández-Méndez M, Assmy P, Øvreås L.   +4 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Long- and short-term variability of Arctic sea-ice cover during the Last Interglacial and Marine Isotope Stage 11c

Communications Earth & Environment
Sea-ice-free Arctic summers are expected within the next decades due to anthropogenic warming. Studying past warm interglacials offers valuable insights into the Arctic climate system under similar conditions. Here we present a series of simulations that
Brian R. Crow, Matthias Prange
doaj   +1 more source