Results 141 to 150 of about 2,283,779 (307)

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

open access: yesFEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada   +7 more
wiley   +1 more source

Shipborne visual observations of Arctic sea ice during POLARSTERN cruise PS80/3

open access: yes, 2018
Shipborne visual observations of Arctic sea ice during POLARSTERN cruise PS80/
Stefan Hendricks (6887366)   +1 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Assimilating Summer Sea‐Ice Thickness Observations Improves Arctic Sea‐Ice Forecast

open access: yesGeophysical Research Letters
Accurate Arctic sea‐ice forecasting for the melt season is still a major challenge because of the lack of reliable pan‐Arctic summer sea‐ice thickness (SIT) data.
Ruizhe Song   +4 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird   +9 more
wiley   +1 more source

A pan-Arctic perspective on the influence of ice algae on sea-ice nutrient concentrations

open access: yes
Sea-ice algae account for a substantial part of annual primary production in ice-covered waters and are an important component of the Arctic marine food web.
Tremblay, Jean-Éric   +21 more
core   +1 more source

Long- and short-term variability of Arctic sea-ice cover during the Last Interglacial and Marine Isotope Stage 11c

open access: yesCommunications Earth & Environment
Sea-ice-free Arctic summers are expected within the next decades due to anthropogenic warming. Studying past warm interglacials offers valuable insights into the Arctic climate system under similar conditions. Here we present a series of simulations that
Brian R. Crow, Matthias Prange
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

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