Results 171 to 180 of about 161,658 (309)

Multi-scale satellite observations of Arctic sea ice: new insight into the life cycle of the floe size distribution. [PDF]

Philos Trans A Math Phys Eng Sci, 2022
Hwang B, Wang Y.
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Enhanced simulated early 21st century Arctic sea ice loss due to CMIP6 biomass burning emissions. [PDF]

Sci Adv, 2022
DeRepentigny P, Jahn A, Holland MM, Kay JE, Fasullo J, Lamarque JF, Tilmes S, Hannay C, Mills MJ, Bailey DA, Barrett AP.   +10 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Influence of the recent winter Arctic sea ice loss in short-term simulations of a regional atmospheric model. [PDF]

Sci Rep, 2022
Cho H, Kug JS, Jun SY.
europepmc   +1 more source

Arctic sea ice needs better forecasts [PDF]

Nature, 2013
openaire   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Robust but weak winter atmospheric circulation response to future Arctic sea ice loss. [PDF]

Nat Commun, 2022
Smith DM, Eade R, Andrews MB, Ayres H, Clark A, Chripko S, Deser C, Dunstone NJ, García-Serrano J, Gastineau G, Graff LS, Hardiman SC, He B, Hermanson L, Jung T, Knight J, Levine X, Magnusdottir G, Manzini E, Matei D, Mori M, Msadek R, Ortega P, Peings Y, Scaife AA, Screen JA, Seabrook M, Semmler T, Sigmond M, Streffing J, Sun L, Walsh A.   +31 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Influence of Arctic sea-ice loss on the Greenland ice sheet climate. [PDF]

Clim Dyn, 2022
Sellevold R, Lenaerts JTM, Vizcaino M.
europepmc   +1 more source