Results 141 to 150 of about 366,068 (244)
Angewandte Chemie, EarlyView.Oncogenic MYC is a transcription factor that is difficult to inhibit. However, precise positioning of an acrylamide electrophile in MAX to covalently bond to the unique Cys438 in MYC, enabled shortening and optimizing of MAX‐derived, helix‐constrained peptides with high‐affinity and selectivity.
Aline Dantas de Araujo +7 more
wiley +2 more sources
Advanced Science, EarlyView.This work establishes an MXene/TiO2 Schottky heterointerface for non‐thermal sonocatalysis. Interface‐confined cavitation and dynamic Ti3+/V₀ shuttles drive charge transport and reactive oxygen species (ROS) generation. The platform achieves 3‐log pathogen reduction while retaining heat‐labile nutrients in complex food matrices, redefining sonocatalyst
Xiaoge Wu +5 more
wiley +1 more source
A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis
Advanced Science, EarlyView.Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee +7 more
wiley +1 more source
Advanced Energy Materials, EarlyView.A gallium‐centered cell pairs an aluminum‐alloyed GaIn anode with a GaOOH cathode in a chloride‐rich water‐in‐ionic‐liquid electrolyte. Chlorogallate ions dissolve the native oxide that normally seals the liquid metal, and preferentially reduce indium seeds to oxide‐free clusters on which gallium plates and strips reversibly.
Adit Gupta +3 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Fibroblast behavior is shaped by the surrounding microenvironment, yet conventional culture systems often fail to capture disease‐relevant phenotypes. Here, platform‐dependent responses of healthy and arthritic synovial fibroblasts are examined across 2D and 3D culture systems. Distinct inflammatory and proliferative signatures emerge, highlighting how
Aneesah Khan +13 more
wiley +1 more source
Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials
Advanced NanoBiomed Research, EarlyView.This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Robust attachment of hydrogels to solid substrates is critical to success in cell culture where hydrostatic and contractile forces can contribute to delamination of weakly adhered gels. This novel approach forms a nanometer‐scale, reagent‐free hydrogel primer layer to provide improved resistance to delamination of subsequent bulk hydrogel layers in a ...
Sophia C. Franklin +7 more
wiley +1 more source
Chemical Switching Between B2N and B2C Homoaromaticity
Angewandte Chemie, EarlyView.We report the synthesis of homoaromatic 1‐aza‐2,4‐diazadiboretane with a bicyclic four‐membered NB2C motif and demonstrate experimentally and theoretically that the homoaromatic delocalization can also be chemically shifted from the B2N to the B2C moiety by deprotonation of the ring carbon atom.
Tim Wiesmeier +5 more
wiley +1 more source
Noradrenaline Regulation of Tyrosine Hydroxylase Expression in Arcuate Nucleus Neurons in Young and Adult Rats. [PDF]
Int J Mol SciPronina TS, Troshev DV, Ugrumov MV.
europepmc +1 more source
Angiotensin-(1-7) Activates Proopiomelanocortin Neurons in the Arcuate Nucleus. [PDF]
HypertensionVernail VL +6 more
europepmc +1 more source