Results 121 to 130 of about 1,302,973 (308)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Area under the exponential curve [PDF]
, 2011 Area, Calculus, Curves and Exponential FunctionsConsider a curve consisting of segments joining the points(n/k,an), where an=(1-1/k)^n and n=1,2,3,... . The region under this curve is broken into triangular pieces by extending the segments to the x axis.
Arik, Okay
core +2 more sources
Journal of Multidisciplinary Healthcare, 2023 Rabia Anwer,1 Lubna Ansari Baig,2 Mehjabeen Musharraf3 1Registered Dietitian Nutritionist, PNS Shifa Hospital, Karachi, 75270, Pakistan; 2Chairperson, APPNA Institute of Public Health, Jinnah Sindh Medical University, Karachi, 75510, Pakistan; 3Senior ...
Anwer R, Baig LA, Musharraf M
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The yield curve as a predictor and emerging economies [PDF]
This paper investigates the extent to which the slope of the yield curve in emerging economies predicts domestic inflation and growth. It also examines international financial linkages and how the US and euro area yield curves help to predict.
Mehl, Arnaud
core
Clinical Interventions in Aging, 2021 Yoshihiro Fukumoto,1,2 Tome Ikezoe,2 Masashi Taniguchi,2 Yosuke Yamada,3 Shinichiro Sawano,4 Seigo Minani,5 Tsuyoshi Asai,6 Misaka Kimura,7,8 Noriaki Ichihashi2 1Department of Physical Medicine and Rehabilitation, Kansai Medical University, Hirakata ...
Fukumoto Y +8 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Evidence Based Medicine; Receiver Operating Characteristic Curve and Area under the Curve
طب اورژانس ایران, 2016 Multiple diagnostic tools are used by emergency physicians, every day. In addition, new tools are evaluated to obtain more accurate methods and reduce time or cost of conventional ones.
Saeed Safari, Alireza Baratloo
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source