Results 61 to 70 of about 15,884,452 (302)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Receiver operating characteristic curve
Current Medicine Research and Practice, 2012 A receiver operating characteristic (ROC) curve is a plot of tradeoff between sensitivity and specificity. It is a plot that evaluates a diagnostic test for a continuous variable between diseased and non-diseased subjects.
Anita Singh +2 more
doaj
Estimating the Area under a Receiver Operating Characteristic Curve For Repeated Measures Design [PDF]
The receiver operating characteristic (ROC) curve is widely used for diagnosing as well as for judging the discrimination ability of different statistical models.
Honghu Liu, Tongtong Wu
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Part 5: Receiver Operating Characteristic Curve and Area under the Curve
Emergency, 2016 Multiple diagnostic tools are used by emergency physicians,every day. In addition, new tools are evaluated to obtainmore accurate methods and reduce time or cost of conventionalones.
Saeed Safari +3 more
doaj
On splitting the area under curves II
Journal of Differential Equations, 1982 AbstractThis paper continues the author's work [3, S. Minsker, J. Differential Equations, 26, No. 3 (1977), 443–457.] on an area-splitting problem leading to the functional differential equation a′(a(x)) = a(x)x. This equation is dealt with by transforming it into the linear equation ψ′(x) = ψ(x + c), for which positive solutions on (−∞, −c) are sought.
openaire +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
AntibioticsObjectives: This retrospective study aimed to estimate vancomycin area under the curve over 24 h (AUC24) at steady state for pediatric patients from 1 month to 18 years to update the dose recommendations in a tertiary hospital.
Rosa Kalliainen +4 more
doaj +1 more source