Results 81 to 90 of about 15,884,452 (302)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Is the Area Under Curve Appropriate for Evaluating the Fit of Psychometric Models? [PDF]
Educ Psychol Meas, 2023 Han Y, Zhang J, Jiang Z, Shi D.
europepmc +1 more source
Instability and nonlinearity in the euro area Phillips curve [PDF]
This paper provides a comprehensive analysis of the functional form of the euro area Phillips curve over the past three decades. In particular, compared to previous literature we analyse the stability of the relationship in detail, especially as regards ...
Stracca, Livio +2 more
core
Features of the area under the receiver operating characteristic (ROC) curve. A good practice
, 2016 The area under the receiver operating characteristic (ROC) curve is a measure of discrimination ability used in diagnostic and prognostic research. The ROC plot is usually represented without additional information about decision thresholds used to ...
Contador, Israel +3 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Diagnostic accuracy of heart rate variability as a screening tool for mild neurocognitive disorder
Frontiers in Aging NeuroscienceBackgroundMild neurocognitive disorder (mNCD) is recognized as an early stage of dementia and is gaining attention as a significant healthcare problem due to current demographic changes and increasing numbers of patients.
Julia Czopek-Rowinska +5 more
doaj +1 more source
Area-Under-Curve-Guided Versus Trough-Guided Monitoring of Vancomycin and Its Impact on Nephrotoxicity: A Systematic Review and Meta-Analysis. [PDF]
Ther Drug Monit, 2023 Lim AS +5 more
europepmc +1 more source
, 2012 Colour photograph of the completed Curve which looms large next to the older buildings of the ...
Hyde, Colin;
core
Conversion of dose-response curve into area under the curve.
, 2014 In order to compare total platelet reactivity between patients, we derived the area under the curve from each dose response curve. MFI = mean fluorescence intensity, AUC = area under curve, ADP = adenosine diphosphate.
Anton Jan van Zonneveld (302780) +17 more
core +1 more source