Results 81 to 90 of about 1,302,973 (308)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Area under the curve of immunosuppressants. [PDF]
, 2016 Area under the curve of immunosuppressants.
Susanne Stampf (3387182) +5 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Estimating the Area under a Receiver Operating Characteristic Curve For Repeated Measures Design [PDF]
The receiver operating characteristic (ROC) curve is widely used for diagnosing as well as for judging the discrimination ability of different statistical models.
Honghu Liu, Tongtong Wu
core +1 more source
Area under the operating characteristics curve. [PDF]
, 2015 Area under the operating characteristics curve.
Jian Liao (20886) +12 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Area Under the Receiver Characteristics Curve (AUROC). [PDF]
Discriminatory performance of models A: the area under the receiver characteristics curve (AUROC) of men; B: the area under the receiver characteristics curve (AUROC) of women.
Geneviève Gariépy (495491) +10 more
core +1 more source
Area under Curve (AUC) comparison. [PDF]
, 2013 Area under Curve (AUC) comparison measuring the ability of recovering the original PPI networks: (a) Y_Tong, (b) H_Bind, (c) H_InAct, (d) F_BioGrid, (e) H_BioGrid using embedding space dimensions of 1 to 20.
Lin Zhu (192179) +3 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source