Results 71 to 80 of about 1,295,849 (308)

CT-severity score in COVID-19 patients: for whom is it applicable best?

open access: yesCaspian Journal of Internal Medicine, 2022
Background: lung involvement in COVID-19 can be quantified by chest CT scan. We evaluated the triage and prognostication performance of seven proposed CT-severity score (CTSS) systems in two age groups of ≥65 and
Alireza Almasi Nokiani   +5 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Area under a curve

open access: yes, 2016
Integral, area, cubic functionThe bottom curve shows the cumulative area under the top curve, which is given by the integral of the function in the top curve.
Wolfram, Stephen
core   +1 more source

On splitting the area under curves

open access: yesJournal of Differential Equations, 1977
AbstractTwo area-splitting problems involving real-valued functions of a real variable are investigated. The second of these is essentially equivalent to finding all functions a ϵ C1((0, r)) with 0 < a(x) < x which satisfy the functional differential equation a′ (a(x)) = a(x)x for x ϵ (0, r). All solutions analytic at x = 0 (and many which are not) are
openaire   +2 more sources

Area under the Curve Greater Than z1.58

open access: yes, 2021
FIGURE 6.4. Area under the curve greater than z = 1.58. (“Area under the Curve Greater than z1.58” by Judy Schmitt is licensed under CC BY-NC-SA 4.0.)https://irl.umsl.edu/oer-img/1061/thumbnail ...
Schmitt, Judy
core  

Area-under-the-curve of tUS traces.

open access: yes, 2022
Level of EMG activity during different sections of tUS trials. Left) Baseline, -200 to -50 ms before onset. Right) 0 to 150 ms after tUS onset (first 150 ms of tUS exposure). Values were normalized via dividing by the trial mean. (PDF)
Tiffany K. Fan (12436762)   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Area under the Curve in the Tails

open access: yes, 2021
FIGURE 4.3. Shaded areas represent the area under the curve in the tails. (“Area under the Curve in the Tails” by Judy Schmitt is licensed under CC BY-NC-SA 4.0.)https://irl.umsl.edu/oer-img/1052/thumbnail ...
Schmitt, Judy
core  

Area under the curve analysis.

open access: yes, 2023
Area under the curve (AUC) analysis was conducted on both intracellular ATP concentration (empty bars) and heat generation curves (striped bars). ΔarcB–red, ΔglnL–blue, ΔyccC–orange, and wild-type–black. Data for all individual replicates can be found in
Tae Seok Moon (2900399)   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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