Results 41 to 50 of about 474,933 (300)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Area Under the curve (AUC) of different OCT measurements.

, 2019
Area Under the curve (AUC) of different OCT measurements.
Alfonso Casado (697004), Andrea Cerveró (7372997), Soraya Fonseca (7373006), Gema Pacheco (7373012), Raúl Fernández (7373003), Miguel Á. Gordo-Vega (7373018), Alicia López-de-Eguileta (7373000), Elena Gándara (7373015), Juan Carlos González (7373009)   +8 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Understanding and application of clinical pharmacokinetic principles using single compartment pharmacokinetic simulation model

National Journal of Physiology, Pharmacy and Pharmacology, 2015
To simplify the principles of pharmacokinetics single compartment model is designed with certain assumptions. Objectives of this model are to understand basic principles of pharmacokinetics, to represent graphically the typical natural log concentration ...
Ashishkumar Zala, ND Kantharia, Aashal B Shah   +2 more
doaj   +1 more source

UV SPECTROPHOTOMETRIC METHODS FOR THE SIMULTANEOUS DETERMINATION OF AMOXICILLIN AND FLUCLOXACILLIN. [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2016
Spectrophotometric methods were introduced for the simultaneous determination of Amoxicillin (AMX) and flucloxacillin(FLX) in their pure forms and  capsules pharmaceutical formulations.
Maya Eissa
doaj   +1 more source

Nonparametric bootstrap methods for interval estimation of the area under the ROC curve with correlated diagnostic test data: application to whole-virus ELISA testing in swine

Frontiers in Veterinary Science, 2023
Developing and evaluating novel diagnostic assays are crucial components of contemporary diagnostic research. The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) are frequently used to evaluate diagnostic assays ...
Jinji Pang, Jinji Pang, Wangqian Ju, Michael Welch, Phillip Gauger, Peng Liu, Qijing Zhang, Chong Wang, Chong Wang   +8 more
doaj   +1 more source

Area Under the Curve (AUC) values after MaxEnt.

, 2014
Area Under the Curve (AUC) values after MaxEnt.
Victor Sanchez-Cordero (5659030), Sahotra Sarkar (78681), Edgar A. Casillas (564694), Miroslava Garza (564692), Chissa-Louise Rivaldi (564695), Teresa Patricia Feria Arroyo (564693)   +5 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

GOLD Classifications, COPD Hospitalization, and All-Cause Mortality in Chronic Obstructive Pulmonary Disease: The HUNT Study

International Journal of COPD, 2020
Laxmi Bhatta,1 Linda Leivseth,2 Xiao-Mei Mai,1 Anne Hildur Henriksen,3,4 David Carslake,5,6 Yue Chen,7 Arnulf Langhammer,8,* Ben Michael Brumpton4,5,9,* 1Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology ...
Bhatta L, Leivseth L, Mai XM, Henriksen AH, Carslake D, Chen Y, Langhammer A, Brumpton BM   +7 more
doaj  

Evaluation of the Methods for Nonlinear Analysis of Heart Rate Variability

Fractal and Fractional, 2023
The dynamics of cardiac signals can be studied using methods for nonlinear analysis of heart rate variability (HRV). The methods that are used in the article to investigate the fractal, multifractal and informational characteristics of the intervals ...
Evgeniya Gospodinova, Penio Lebamovski, Galya Georgieva-Tsaneva, Mariya Negreva   +3 more
doaj   +1 more source