Results 61 to 70 of about 478,663 (300)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The area under curve (AUC) measurements of the six methods under various simulation configurations. [PDF]

, 2012
The area under curve (AUC) measurements of the six methods under various simulation configurations.
Xiguo Yuan (110368), Yue Wang (65477), Junying Zhang (28976), Shengli Zhang (110370), Guoqiang Yu (110375)   +4 more
core   +1 more source

Understanding and application of clinical pharmacokinetic principles using single compartment pharmacokinetic simulation model

National Journal of Physiology, Pharmacy and Pharmacology, 2015
To simplify the principles of pharmacokinetics single compartment model is designed with certain assumptions. Objectives of this model are to understand basic principles of pharmacokinetics, to represent graphically the typical natural log concentration ...
Ashishkumar Zala, ND Kantharia, Aashal B Shah   +2 more
doaj   +1 more source

UV SPECTROPHOTOMETRIC METHODS FOR THE SIMULTANEOUS DETERMINATION OF AMOXICILLIN AND FLUCLOXACILLIN. [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2016
Spectrophotometric methods were introduced for the simultaneous determination of Amoxicillin (AMX) and flucloxacillin(FLX) in their pure forms and  capsules pharmaceutical formulations.
Maya Eissa
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Area under Curve (AUC) – diagnostic performance of serum Cu level and serum cTn-I level according to AUC. [PDF]

, 2013
Area under Curve (AUC) – diagnostic performance of serum Cu level and serum cTn-I level according to AUC.
Noor Azuan Abu Osman (284241), Forough Ataollahi (284231), Belinda Pingguan-Murphy (284237), Mehrdad Mohri (284233), Wan Abu Bakar Wan Abas (284239), Hesam A. Seifi (284235)   +5 more
core   +1 more source

Area under the curve (AUC) values for species/genus separation across ten genera. [PDF]

, 2023
Area under the curve (AUC) values for species/genus separation across ten genera.
Julie E. Hernández-Salmerón (9562999), Tanya Irani (16985548), Gabriel Moreno-Hagelsieb (578)   +2 more
core   +1 more source

Towards non-invasive diagnosis of glioblastoma: identifying metabolic biomarkers in liquid biopsies using a ROC-based approach

Discover Oncology
For over seven decades, the World Health Organization (WHO) has classified central nervous system tumors primarily based on histological criteria. While recent updates have incorporated molecular genetics and histochemistry, this approach still overlooks
Margareth Borges Coutinho Gallo
doaj   +1 more source

A relationship between the incremental values of area under the ROC curve and of area under the precision-recall curve

Diagnostic and Prognostic Research, 2021
Background Incremental value (IncV) evaluates the performance change between an existing risk model and a new model. Different IncV metrics do not always agree with each other. For example, compared with a prescribed-dose model, an ovarian-dose model for
Qian M. Zhou, Lu Zhe, Russell J. Brooke, Melissa M. Hudson, Yan Yuan   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source