Results 181 to 190 of about 12,764 (213)
Multiple activities for Arf1 at the Golgi complex
Biochimica Et Biophysica Acta - Molecular Cell Research, 2005 The Arf family of GTPases regulates membrane traffic and organelle structure. At the Golgi complex, Arf proteins facilitate membrane recruitment of many cytoplasmic coat proteins to allow sorting of membrane proteins for transport, stimulate the activity of enzymes that modulate the lipid composition of the Golgi, and assemble a cytoskeletal scaffold ...
Julie Donaldson, Roberto Weigert
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ARF1 and SAR1 GTPases in Endomembrane Trafficking in Plants [PDF]
International Journal of Molecular Sciences, 2013 Small GTPases largely control membrane traffic, which is essential for the survival of all eukaryotes. Among the small GTP-binding proteins, ARF1 (ADP-ribosylation factor 1) and SAR1 (Secretion-Associated RAS super family 1) are commonly conserved among all eukaryotes with respect to both their functional and sequential characteristics.
Birsen Cevher-Keskin
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Integrating Three Views of Arf1 Activation Dynamics
Journal of Molecular Biology, 2004The proteins Arno and Gea2 of the Sec7 family can promote GDP-GTP exchange on Arf1, a small GTP-binding protein, which coordinates coated vesicle formation for protein transport within the cell. Crystal structures of the essential Sec7 domain (Sec7d) of Gea2 in the free and Arf1-bound forms suggest that conformational dynamics of the Sec7d as well as ...
Robert, Charles +3 more
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Preparation of Myristoylated Arf1 and Arf6
2005Arf proteins are members of the Arf family of small Ras-like GTP binding proteins. Six Arfs, grouped into three classes, have been identified in mammalian cells and three members have been identified in yeasts. Arf1 and Arf6, more extensively studied than other Arfs, have been found to affect membrane traffic and actin remodeling.
Vi Luan, Ha +3 more
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1995
Abstract Bovine ARF1 was cloned by screening a bovine adrenal chromaffin cDNA library with an oligonucleotide probe, derived from partial protein sequencing of purified bovine brain ARF (Sewell and Kahn 1988; accession number J03275). The bovine clone was then used as a probe to obtain genomic yeast {Saccharomyces cerevisiae; Sewell and ...
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Abstract Bovine ARF1 was cloned by screening a bovine adrenal chromaffin cDNA library with an oligonucleotide probe, derived from partial protein sequencing of purified bovine brain ARF (Sewell and Kahn 1988; accession number J03275). The bovine clone was then used as a probe to obtain genomic yeast {Saccharomyces cerevisiae; Sewell and ...
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ARF1 is directly involved in dynamin-independent endocytosis
Nature Cell Biology, 2007Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid phase takes place primarily through a dynamin- and clathrin-independent, Cdc42-regulated pinocytic mechanism. This mechanism is mediated by primary carriers called clathrin-independent carriers (CLICs), which fuse to form tubular early endocytic compartments ...
Sudha, Kumari, Satyajit, Mayor
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ARF1 regulatory factors and COPI vesicle formation
Current Opinion in Cell Biology, 2002Understanding the biosynthetic pathways involved in cellular transport is an important issue in cell biology. More than a hundred years after the discovery of the Golgi apparatus, we still do not understand the regulation of vesicular transport to, within and from the Golgi apparatus.
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ADRP is dissociated from lipid droplets by ARF1-dependent mechanism
Biochemical and Biophysical Research Communications, 2004Adipocyte differentiation-related protein (ADRP) is a member of PAT proteins existing in lipid droplets (LDs). By yeast two-hybrid screening, we identified ADP-ribosylation factor 1 (ARF1) as a binding partner of ADRP. The interaction of ADRP and ARF1 was verified by GST pull-down and co-immunoprecipitation experiments. Interestingly, ADRP precipitated
Hiroshi Kogo, Toyoshi Fujimoto
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An Arf1 GTPase mutant with different responses to GEF inhibitors
Biochemical and Biophysical Research Communications, 2008Guanine nucleotide exchange factors (GEFs) stimulate the activation of small GTP-binding proteins (GTPases). Establishing their specificity is a challenging issue, in which chemical genetics are rapidly gaining interest. We report a mutation in the Arf1 GTPase, K38A, which differentially alters its sensitivity to GEF inhibitors.
Sebastian, Flisiak +4 more
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In Vitro Assays of Arf1 Interaction with GGA Proteins
2005ADP-ribosylation factor 1 (Arf1) is a GTP-binding protein that regulates membrane traffic. This function of Arf1 is, at least in part, mediated by Arf1 x GTP binding to coat proteins such as coatomer, clathrin adaptor protein (AP) complexes 1 and 3, and gamma-adaptin homology-Golgi associated Arf-binding (GGA) proteins.
Hye-Young, Yoon +2 more
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