Results 91 to 100 of about 116,128,249 (216)

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source

The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection

BMC Immunology, 2011
Background Alternatively activated macrophages (AAMϕ) play important roles in allergies and responses to parasitic infections. However, whether signaling through toll-like receptors (TLRs) plays any role in AAMϕ induction when young Fasciola hepatica ...
Luo HongLin, Huang Weiyi, Wang Dongying, Wang Haoju, Nie Kui   +4 more
doaj   +1 more source

Frequent adaptive immune responses against arginase-1

, 2017
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived ...
Nicolai Grønne Dahlager Jørgensen, Hansen, Morten, Mads Hald Andersen, Morten Hansen, Martinenaite, Evelina, Munir Ahmad, Shamaila, Mortensen, Rasmus Erik Johansson, Evelina Martinenaite, Marco Donia, Shamaila Munir Ahmad, Andersen, Mads Hald, Met, Özcan, Rasmus Erik Johansson Mortensen, Orebo Holmström, Morten, Morten Orebo Holmström, Donia, Marco, Özcan Met, Svane, Inge Marie, Grønne Dahlager Jørgensen, Nicolai, Inge Marie Svane   +19 more
core   +1 more source

Human Salivary Arginase and Its Deficiency in Argininaemia1) [PDF]

, 1984
Summary: Arginase from normal human mixed saliva was characterized. The enzyme was completely activated after a preincubation of 20min at 55 °C and a Mn2+ final concentration of 5 mmol/1.
Konarska, L., Tomaszewski, L., L. Tomaszewski, Terheggen, H. G., J. P. Colombo, H. G. Terheggen, Colombo, J. P., L. Konarska   +7 more
core   +1 more source

DataSheet10_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.ZIP

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Table5_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.XLSX

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

Relationship between elevated arginine and pathophysiology of progressive disease in arginase 1 deficiency

Molecular Genetics and Metabolism
Arginase 1 deficiency (ARG1-D; OMIM #207800) is a rare urea cycle disorder caused by loss of arginase activity, preventing the hydrolysis of arginine to ornithine and urea. The resulting hyperargininaemia leads to accumulation of neurotoxic metabolites including guanidino compounds and nitric oxide in the central nervous system.
Mattias, Rudebeck, Spyros, Batzios, Leslie, Sloan, Linda, Neuman   +3 more
openaire   +2 more sources

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Alpha-1 antitrypsin deficiency gut microbiome

, 2020
This dataset contains 16S rRNA Illumina MiSeq sequenced samples used in our gut microbiome study in individuals with alpha-1 antitrypsin deficiency (AATD) and controls (non-AATD)
Kirst, ME (University of Florida)
core   +1 more source