Results 101 to 110 of about 116,128,249 (216)

Image1_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.TIF

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

Citrulline supplementation improves organ perfusion and arginine availability under conditions with enhanced arginase activity [PDF]

, 2015
Enhanced arginase-induced arginine consumption is believed to play a key role in the pathogenesis of sickle cell disease-induced end organ failure. Enhancement of arginine availability with l-arginine supplementation exhibited less consistent results ...
Benjamin Vandendriessche, Bessems, Babs AFM, Poeze, Martijn, Brouckaert, Peter, Karolina Wijnands, Ruben Visschers, Babs Bessems, Wijnands, Karolina AP, Bouvy, Nicole D, Nicole Bouvy, van Barneveld, Kevin WY, van Eijk, Hans MH, Visschers, Ruben G. J., Visschers, Ruben GJ, Meesters, Dennis M, Peter Brouckaert, Bessems, Babs A. F. M., Vandendriessche, Benjamin, van Barneveld, Kevin W. Y., Meesters, Dennis M., Nadine Hoven, Martijn Poeze, Lamers, Wouter H, Wouter Lamers, Anje Cauwels, Kevin Van Barneveld, Cauwels, Anje, Christian Von Wintersdorff, Hans Van Eijk, von Wintersdorff, Christian JH, van Eijk, Hans M. H., Briede, Jacob J., von Wintersdorff, Christian J. H., Jacob Briedé, Lamers, Wouter H., Bouvy, Nicole D., Dennis Meesters, Briedé, Jacob J, van den Hoven, Nadine, Wijnands, Nina   +39 more
core   +1 more source

DataSheet8_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.ZIP

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

Comparing CRISPR-Cas9 Gene Therapy Delivery Systems: Implications and Optimization for Hyperargininemia

Precision Nanomedicine
Hyperargininemia is a rare autosomal recessive metabolic disorder caused by a deficiency in the urea cycle enzyme arginase 1, resulting in severe systemic and neurological complications.
Jad Madani, Humza N. Zubair, Ghazi A. Saroya, Rachel E.N. Reyes, Rami Madani   +4 more
doaj   +1 more source

Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.

PLoS ONE, 2014
Apolipoliprotein E (apoE), a critical targeting protein in lipid homeostasis, has been found to have immunoinflammatory effects on murine models of infection and malnutrition. The effects of apoE in undernourished and Cryptosporidium parvum-infected mice
Orleâncio G R Azevedo, David T Bolick, James K Roche, Relana F Pinkerton, Aldo A M Lima, Michael P Vitek, Cirle A Warren, Reinaldo B Oriá, Richard L Guerrant   +8 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Roles of Arginase-1 in Neural Cells [PDF]

, 2019
Arginase-1 (ARG1) is an essential urea cycle (UC) enzyme that catalyzes the hydrolysis of arginine, proposed to also be involved in pre- and post-natal development and post-injury regeneration of neural cells.
Richmond, Christopher
core  

DataSheet5_Hepatic Ischemia-Reperfusion Impairs Blood-Brain Barrier Partly Due to Release of Arginase From Injured Liver.ZIP

, 2021
Aim: Hepatic ischemia-reperfusion (HIR) induces remote organs injury, including the brain. The homeostasis of the brain is maintained by the blood-brain barrier (BBB); thus, we aimed to investigate whether HIR impaired BBB and attempted to elucidate its ...
Yun Sheng (4267843), Weimin Kong (2558737), Liang Zhu (172992), Li Liu (75607), Xiaodong Liu (403701), Hanyu Yang (8374881), Peihua Liu (11556460), Han Zhou (109068), Feng Xu (89016), Lu Yang (30847), Xiaonan Liu (142071), Ping Li (31981)   +11 more
core   +1 more source

Argininemia: Pathophysiology and Novel Methods for Evaluation of the Disease

Applied Sciences
Argininemia or arginase-1 deficiency constitutes a rare, genetic, metabolic disorder caused by mutations in arginase 1—the last enzyme of the urea cycle—that hydrolyses L-arginine to ornithine and urea.
Despoina Nteli, Maria Nteli, Konstantinos Konstantinidis, Anastasia Foka, Foteini Charisi, Iliana Michailidou, Sotiria Stavropoulou De Lorenzo, Marina Boziki, Maria Tzitiridou-Chatzopoulou, Evangelia Spandou, Constantina Simeonidou, Christos Bakirtzis, Evangelia Kesidou   +12 more
doaj   +1 more source

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

Protein & Cell, 2016
Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors.
Julia Foldi, Yingli Shang, Baohong Zhao, Lionel B. Ivashkiv, Xiaoyu Hu   +4 more
doaj   +1 more source