Results 161 to 170 of about 116,128,249 (216)

4‐1BBL Suppresses Anti‐Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages

Immunology, Volume 179, Issue 3, Page 434-443, November 2026.
4‐1BB ligand (4‐1BBL) is known to promote sustained pro‐inflammatory responses in macrophages. This study demonstrates that 4‐1BBL acts as a negative regulator of anti‐inflammatory macrophage responses. Genetic deletion or pharmacological inhibition of 4‐1BBL significantly enhanced the phosphorylation of IL‐4R‐proximal JAK1 and STAT6, elevating the ...
Young Jun Kang
wiley   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Dietary Arginine Sets the Pace of MHC Class I Translation: A Nutrient Lever on Tumour Immunogenicity

MedComm, Volume 7, Issue 11, November 2026.
Mohammad Asim
wiley   +1 more source

CRISPR/Cas9-Mediated Gene Editing in the Arginase-1 Deficient Mouse Genome

, 2015
Arginase-1 deficiency is a rare, autosomal recessive disorder of the urea cycle that normally converts ammonia to less toxic urea. Symptoms include neurodegeneration, spastic diplegia and mental retardation. We designed a Clustered Regularly Interspaced Palindromic Repeat (CRISPR)/Cas9 system to correct an induced Arg1 exon 7 and 8 deletion (Arg1 ...
openaire   +1 more source

P046: ACMG/AMP variant classification framework in arginase 1 deficiency: Implications for birth prevalence estimates and diagnostics

Genetics in Medicine Open
Mayowa Osundiji, Jessie Cameron, Rory Olson, Bukola Olarewaju, Andreas Schulze   +4 more
doaj   +1 more source

Alox15 restrains glycolysis to support M2 macrophage effector function during helminth immunity. [PDF]

J Exp Med
Ovezgeldiyev D, Trefzer V, Doolan R, Moyat M, Coakley G, Wickramasinghe LC, Daunt C, Volpe B, Henkel F, Serra A, Hartmann M, Rezaei S, Ubags N, Butler A, Chatzis R, Marsland BJ, Smith AAT, Deveson Lucas D, McGowan ENS, Binger KJ, McConville MJ, Esser-von Bieren J, Harris NL, Bouchery T.   +23 more
europepmc   +1 more source

The Janus face of L-arginine supplementation in cardiovascular health and aging exploration of underlying mechanisms. [PDF]

Front Aging
Yang Z, Ming XF, Potenza DM.
europepmc   +1 more source

Blood Cells Far from Equilibrium: Redox Adaptation in Health and Disease. [PDF]

Antioxidants (Basel)
Anastasiadi AT, D'Alessandro A.
europepmc   +1 more source

Arginase 2 deficiency mitigates sepsis-associated acute kidney injury by alleviating lipid accumulation. [PDF]

Clin Transl Med
Xin Y, Liu Y, Zhang N, Huang P, Zhang Q, Luo Y, Wang X, Zhang X, Wu T, Liu F, Xiao Y, Shen L, Zhang W, Wang X, Meng X, Bai Y, Wang X, Zhang N, Xu Q, Meng H, Zheng X, Cheng L, Yu K, Wang C.   +23 more
europepmc   +1 more source

Extracellular Vesicles Delivered a Functional ARG1 Enzyme and Restored Its Activity in a Mouse Model of ARG1-D Resulting in Improved Lifespan. [PDF]

Int J Mol Sci
Hsieh LE, Cacciottolo M, LeClaire MJ, Morrison W, Murphy B, Lau C, Elliott K, Marban L, Sun M.   +8 more
europepmc   +1 more source