Results 221 to 230 of about 78,666 (255)
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Molecular and Cellular Biochemistry, 1980
We report here, for the first time the presence of arginase in human platelets. This enzyme has been partially purified and some of it properties studied. Its biological significance and its involvement in polyamine biosynthesis are considered.
V R, Villanueva, M, Giret
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We report here, for the first time the presence of arginase in human platelets. This enzyme has been partially purified and some of it properties studied. Its biological significance and its involvement in polyamine biosynthesis are considered.
V R, Villanueva, M, Giret
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British Journal of Pharmacology, 2009
Allergic asthma is a chronic inflammatory airways' disease, characterized by allergen-induced early and late bronchial obstructive reactions, airway hyperresponsiveness (AHR), airway inflammation and airway remodelling. Recent ex vivo and in vivo studies in animal models and asthmatic patients have indicated that arginase may play a central role in all
Maarsingh, Harm +2 more
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Allergic asthma is a chronic inflammatory airways' disease, characterized by allergen-induced early and late bronchial obstructive reactions, airway hyperresponsiveness (AHR), airway inflammation and airway remodelling. Recent ex vivo and in vivo studies in animal models and asthmatic patients have indicated that arginase may play a central role in all
Maarsingh, Harm +2 more
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Arginase in Glomerulonephritis
Nephron Experimental Nephrology, 2000Arginase metabolizes <i>L</i>-arginine to <i>L</i>-ornithine and urea. Two arginase isoforms, AI (liver arginase) and AII (ubiquitously expressed, functions unknown), have been identified. It is clear that arginases potentially have important roles in addition to urea generation for high concentrations are present at ...
S N, Waddington, V, Cattell
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Liver arginase. III. Properties of highly purified arginase
Archives of Biochemistry and Biophysics, 1956Abstract 1. 1. Arginase has been prepared from horse liver which exhibited one major component and a minor, slower-moving component upon electrophoresis at pH 7.35. Ultracentrifugal analysis also showed the presence of only two components, the lesser of which could be made to sediment as a pellet on the bottom of the cell. This material exhibited
D M, GREENBERG, A E, BAGOT, O A, ROHOLT
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2013
The presence of different sets of several enzymes that participate in the Krebs-Henseleit cycle has been used to identify several genera of trypanosomatids. One of these enzymes is arginase (L-arginine amidinohydrolase, E.C. 3.5.3.1), a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea.
Maria Fernanda Laranjeira, da Silva +1 more
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The presence of different sets of several enzymes that participate in the Krebs-Henseleit cycle has been used to identify several genera of trypanosomatids. One of these enzymes is arginase (L-arginine amidinohydrolase, E.C. 3.5.3.1), a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea.
Maria Fernanda Laranjeira, da Silva +1 more
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Experientia, 1948
Nombreux sont les travaux qui traitent de la separation et de la purification de l'arginase. Le present travail decrit une methode de purification qui permet d'obtenir une arginase active contenant des traces d'impuretes (80% d'arginase active).
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Nombreux sont les travaux qui traitent de la separation et de la purification de l'arginase. Le present travail decrit une methode de purification qui permet d'obtenir une arginase active contenant des traces d'impuretes (80% d'arginase active).
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Small-molecule Arginase Inhibitors
Pharmaceutical Patent Analyst, 2013Arginase is an enzyme that metabolizes L-arginine to L-ornithine and urea. In addition to its fundamental role in the hepatic ornithine cycle, it also influences the immune systems in humans and mice. Arginase participates in many inflammatory disorders by decreasing the synthesis of nitric oxide and inducing fibrosis and tissue regeneration.
Yan A, Ivanenkov, Nina V, Chufarova
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Journal of Medicinal Chemistry, 2019
Recent efforts to identify highly potent and efficacious inhibitors of arginase have resulted in the discovery of a novel series of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogs with up to a 1,000-fold increase in potency ...
M. V. Van Zandt +10 more
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Recent efforts to identify highly potent and efficacious inhibitors of arginase have resulted in the discovery of a novel series of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogs with up to a 1,000-fold increase in potency ...
M. V. Van Zandt +10 more
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Comparative properties of arginases
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996Arginase is a primordial enzyme, widely distributed in the biosphere and represented in all primary kingdoms. It plays a critical role in the hepatic metabolism of most higher organisms as a cardinal component of the urea cycle. Additionally, it occurs in numerous organisms and tissues where there is no functioning urea cycle. Many extrahepatic tissues
C P, Jenkinson +2 more
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Food & Function, 2019
Quercetin related compounds were tested against Leishmania amazonensis arginase, a potential target for the development of new approaches in treating leishmaniasis.
E. R. da Silva +5 more
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Quercetin related compounds were tested against Leishmania amazonensis arginase, a potential target for the development of new approaches in treating leishmaniasis.
E. R. da Silva +5 more
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