Results 81 to 90 of about 78,666 (255)

A role for peroxisome proliferator-activated receptors in the immunopathology of schistosomiasis? [PDF]

, 2012
Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages.
Allen, JT, Anthony, BJ, Li, Y, McManus, D   +3 more
core   +4 more sources

Arginase and pulmonary diseases [PDF]

Naunyn-Schmiedeberg's Archives of Pharmacology, 2008
Recent studies have indicated that arginase, which converts L-arginine into L-ornithine and urea, may play an important role in the pathogenesis of various pulmonary disorders. In asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis, increased arginase activity in the airways may contribute to obstruction and hyperresponsiveness of ...
Maarsingh, Harm, Pera, Tonio, Meurs, Herman   +2 more
openaire   +3 more sources

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

Frontiers in Immunology, 2014
Macrophages play a major role in the immune system, both as antimicrobial effector cells and as immunoregulatory cells, which induce, suppress or modulate adaptive immune responses.
Meera Rath, I. Müller, P. Kropf, E. Closs, M. Munder   +4 more
semanticscholar   +1 more source

Is the Arginase Pathway a Novel Therapeutic Avenue for Diabetic Retinopathy?

Journal of Clinical Medicine, 2020
Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans. Clinicians diagnose DR based on its characteristic vascular pathology, which is evident upon clinical exam.
E. Shosha, A. Fouda, S. Narayanan, R. Caldwell, R. Caldwell, R. Caldwell   +5 more
semanticscholar   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

The kinetic properties of arginase in sperm cells of inferile men

Regulatory Mechanisms in Biosystems, 2018
Nowadays the role of NO in the development of male infertility is actively studied. Arginase (EC 3.5.3.1) is a manganese metalloenzyme which converts L-arginine to L-ornithine and urea and reciprocally regulates NO production.
R. V. Fafula, U. P. Iefremova, O. K. Onufrovych, H. V. Maksymyuk, D. Z. Vorobets, Z. D. Vorobets   +5 more
doaj   +1 more source

Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Frontiers in Chemistry, 2021
Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase may ...
Andreza R. Garcia, Danielle M. P. Oliveira, Jessica B. Jesus, Jessica B. Jesus, Alessandra M. T. Souza, Ana Carolina R. Sodero, Alane B. Vermelho, Ivana C. R. Leal, Rodrigo Octavio M. A. Souza, Leandro S. M. Miranda, Anderson S. Pinheiro, Igor A. Rodrigues, Igor A. Rodrigues   +12 more
doaj   +1 more source

Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity [PDF]

, 2015
Neuroblastoma is the most common extra cranial solid tumour of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results. Here,
Borsheim, Bowman, Carmel McConville, Carmela De Santo, Francis Mussai, Gavin Bendle, Hannah Webber, John Anderson, Jonathan Fisher, Kate Wheeler, Kevin Petrie, Lin, Liu, Lofberg, Louis Chesler, Morris, Morris, Mujoo, Pistoia, Rachel Wheat, Rodolfo, Rodolfo, Serafini, Sharon Egan, Stuart Hunter, Yordan Sbirkov   +25 more
core   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources