Results 81 to 90 of about 65,972 (187)

Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury. [PDF]

, 2018
Impact statementSpinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their ...
Anderson, Aileen J, Carlson, Mitchell A, Cummings, Brian J, Dumont, Courtney M, Munsell, Mary K, Shea, Lonnie D   +5 more
core   +1 more source

The ornithine cycle in Neurospora and its genetic control [PDF]

, 1944
It has been emphasized by Haldane (1) that for studies of intermediary metabolism "the new science of genetics furnishes a very powerful method." Such a method is founded upon the general premises that genes control many of the chemical reactions within ...
Horowitz, N. H., Srb, Adrian
core  

Nitric Oxide Synthase Activity Correlates with OGG1 in Ozone-Induced Lung Injury Animal Models

Frontiers in Physiology, 2017
Background: NO is an important cellular signaling molecule which is derived from L-arginine by nitric oxide synthase (NOS) and the effects of NOS signaling in lung injury is conflicting.
Jianhua Li, Suqin Zhang, Yuqin Li, Yufeng Liu, Hongxiang Guo, Xiaoli Xu   +5 more
doaj   +1 more source

Arginase and vascular aging

Journal of Applied Physiology, 2008
Vascular and associated ventricular stiffness is one of the hallmarks of the aging cardiovascular system. Both an increase in reactive oxygen species production and a decrease in nitric oxide (NO) bioavailability contribute to the endothelial dysfunction that underlies this vascular stiffness, independent of other age-related vascular pathologies such ...
Lakshmi, Santhanam, David W, Christianson, Daniel, Nyhan, Dan E, Berkowitz   +3 more
openaire   +3 more sources

Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. [PDF]

, 2019
Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use.
Bertoni, Carmen, Flores, Ivan, Ramos, Julian, Tidball, James G, Wang, Ying, Wehling-Henricks, Michelle, Welc, Steven S   +6 more
core  

Synthesis, In Silico, and In Vitro Evaluation of Anti-Leishmanial Activity of Oxadiazoles and Indolizine Containing Compounds Flagged against Anti-Targets

Molecules, 2019
Due to the lack of approved vaccines against human leishmaniasis and the limitations of the current chemotherapy inducing side effects and drug resistance, development of new, effective chemotherapeutic agents is essential.
Strahinja Stevanovic, Milan Sencanski, Mathieu Danel, Christophe Menendez, Roumaissa Belguedj, Abdelmalek Bouraiou, Katarina Nikolic, Sandrine Cojean, Philippe M. Loiseau, Sanja Glisic, Michel Baltas, Alfonso T. García-Sosa   +11 more
doaj   +1 more source

Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

Frontiers in Immunology, 2018
Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected hosts.
Philippe Holzmuller, Philippe Holzmuller, Anne Geiger, Romaric Nzoumbou-Boko, Romaric Nzoumbou-Boko, Romaric Nzoumbou-Boko, Joana Pissarra, Sarra Hamrouni, Valérie Rodrigues, Valérie Rodrigues, Frédéric-Antoine Dauchy, Frédéric-Antoine Dauchy, Frédéric-Antoine Dauchy, Jean-Loup Lemesre, Philippe Vincendeau, Philippe Vincendeau, Philippe Vincendeau, Rachel Bras-Gonçalves   +17 more
doaj   +1 more source

Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

eLife
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury.
Duilio M Potenza, Xin Cheng, Guillaume Ajalbert, Andrea Brenna, Marie-Noelle Giraud, Aurelien Frobert, Stephane Cook, Kirsten D Mertz, Zhihong Yang, Xiu-Fen Ming   +9 more
doaj   +1 more source

Arginase-II Deficiency Extends Lifespan in Mice

Frontiers in Physiology, 2017
The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66Shc and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-
Yuyan Xiong, Gautham Yepuri, Jean-Pierre Montani, Jean-Pierre Montani, Xiu-Fen Ming, Xiu-Fen Ming, Zhihong Yang, Zhihong Yang   +7 more
doaj   +1 more source

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. [PDF]

, 2014
It is well known that the ω-3 fatty acids (ω-3-FAs; also known as n-3 fatty acids) can exert potent anti-inflammatory effects. Commonly consumed as fish products, dietary supplements and pharmaceuticals, ω-3-FAs have a number of health benefits ascribed ...
Akiyama, Taro E, Armando, Aaron M, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Cox, Jason M, Di Salvo, Jerry, Evans, Ronald M, Hah, Nasun, Lackey, Denise, Lagakos, William S, McNelis, Joanne, Oh, Da Young, Olefsky, Jerrold M, Pessentheiner, Ariane R, Powels, Mary Ann, Quehenberger, Oswald, Sasik, Roman, Sinz, Christopher, Walenta, Evelyn, Watkins, Steven M   +20 more
core   +1 more source