Results 91 to 100 of about 50,915 (302)
Arginase-2 mediates diabetic renal injury [PDF]
, 2011 OBJECTIVE—To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS—The impact of argi-nase activity and expression
Sidney M. Morris +4 more
core +1 more source
An Update on Arginase Inhibitors and Inhibitory Assays
, 2021 International audienceAbstract: Arginase, which converts arginine into ornithine and urea, is a promising therapeutic target. Arginase is involved in cardiovascular diseases, parasitic infections and, through a critical role in immunity, in some cancers.
Pudlo, M. +9 more
core +1 more source
Modulation of arginase by various pathogens.
, 2013 Modulation of arginase by various pathogens.
Dipshikha Chakravortty (230557) +3 more
core +2 more sources
Advanced Science, EarlyView.In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu +8 more
wiley +1 more source
Regulation of arginase II expression in macrophages by supernatants of apoptotic cells [PDF]
, 2010 Apoptotic cell (AC)-derived factors alter the physiology of macrophages (M Phi s) towards a regulatory phenotype that is characterized by enhanced production of anti-inflammatory mediators, an attenuated pro-inflammatory cytokine profile and reduced ...
Barra, Vera
core
Protein & Cell, 2016 Development of alternatively activated (M2) macrophage phenotypes is a complex process that is coordinately regulated by a plethora of pathways and factors.
Julia Foldi +4 more
doaj +1 more source
Advanced Science, EarlyView.When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li +11 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
BMC BiotechnologyBackground L-arginase, is a powerful anticancer that hydrolyzes L-arginine to L-ornithine and urea. This enzyme is widely distributed and expressed in organisms like plants, fungi, however very scarce from bacteria.
Manal S. Selim +5 more
doaj +1 more source
Experimental Biology and Medicine, 1957 SummarySerum arginase activity has been determined in 34 healthy blood donors. A mean value 0.06 ± 0.09 μmole urea formed/ml serum was found with a range of .00 to 0.36 μmole. In sera of 19 patients with proven or suspected liver disease the mean arginase activity was 1.36 with a range of .00 to 6.08 μmoles formed/ml serum under the condition of assay.
R T, MANNING, S, GRISOLIA
openaire +2 more sources