Results 111 to 120 of about 50,915 (302)

Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.

, 2019
Arginase has therapeutic potential as a cytotoxic agent in some cancers, but this is unclear for precursor B acute lymphoblastic leukaemia (pre-B ALL), the commonest form of childhood leukaemia.
Carlebur, Saskia, Brown, Guy C., Métayer, Lucy E., Brown, Richard D., Burke, G. A.Amos; id_orcid   +4 more
core   +2 more sources

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

Inhibition and Kinetic Studies of Tortoise (Kinixys erosa) Liver arginase [PDF]

, 2012
The effect of amino acid on tortoise liver arginase showed that L-lysine, L-valine, L-serine, L-aspartic acid and L aspartic acid had significant inhibitory effect on the enzyme but proline and glutamic acid showed slight inhibition ...
Okonji, RRE, Agboola, FK, Adeyinka, A
core   +1 more source

Neuroblastoma arginase activity creates an immunosuppressive microenvironment impairing autologous and engineered immunity [PDF]

, 2015
Neuroblastoma is the most common extracranial solid tumor of childhood, and survival remains poor for patients with advanced disease. Novel immune therapies are currently in development, but clinical outcomes have not matched preclinical results.
Hunter, Stuart, Petrie, K, Wheat, R, Chesler, Louis, Sbirkov, Yordan, Egan, S, Chesler, L, Egan, Sharon, De Santo, Carmela, Egan, Sharon A., Wheeler, K, Fisher, Jonathan, Bendle, Gavin, De Santo, C, Wheeler, Kate, Petrie, Kevin, Webber, H, Wheat, Rachel, Sbirkov, Y, Fisher, J, Mussai, Francis, Bendle, G, Anderson, J, Mussai, F, McConville, C, Hunter, S, Anderson, John, McConville, Carmel, Webber, Hannah   +28 more
core   +1 more source

Arginase pathway in human endothelial cells in pathophysiological conditions.

, 2004
Objective. – Arginase is a nitric oxide synthase-alternative pathway for L-arginine breakdown leading to biosynthesis of urea and L-ornithine. Arginase pathway is inducible by inflammatory molecules—such as cytokines and bacterial endotoxin—in ...
CURELLO S, GRIGOLATO P, GRIGOLATO, Pier Giovanni, COMINI L, ALBERTINI A, BASTIANON D, FRANCOLINI G, FINAZZI D, VALETTI B, SUZUKI, Hisanori, FERRARI R., FINAZZI, Dario, BACHETTI T, SUZUKI H, CADEI M   +14 more
core   +2 more sources

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Contribution of arginase to manganese metabolism of Aspergillus niger

, 2016
Aspects of manganese metabolism during normal and acidogenic growth of Aspergillus niger were explored. Arginase from this fungus was a Mn[II]-enzyme. The contribution of the arginase protein towards A.
PUNEKAR, NS, KENI, S
core   +1 more source

Elevated plasma arginase-1 does not affect plasma arginine in patients undergoing liver resection.

, 2008
Arginine is an important substrate in health and disease. It is a commonly held view that arginase-1 release from injured erythrocytes and hepatocytes leads to arginine breakdown. However, the true relationship between plasma arginase-1 concentration and
Monbaliu, D., Buurman, W.A., van de Poll, M.C., Berbee, M., Hanssen, S.J., Dejong, C.H., Deutz, N.E.P.   +6 more
core   +2 more sources

Purification, properties and alternate substrate specificities of arginase from two different sources: Vigna catjang cotyledon and buffalo liver

International Journal of Biological Sciences, 2005
Arginase was purified from Vigna catjang cotyledons and buffalo liver by chromatographic separations using Bio-Gel P-150, DEAE-cellulose and arginine AH Sepharose 4B affinity columns.
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