Results 121 to 130 of about 50,915 (302)

Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

eLife
Aging is a predominant risk factor for heart disease. Aging heart reveals low-grade chronic inflammation, cell apoptosis, cardiac fibrosis, and increased vulnerability to ischemic injury.
Duilio M Potenza, Xin Cheng, Guillaume Ajalbert, Andrea Brenna, Marie-Noelle Giraud, Aurelien Frobert, Stephane Cook, Kirsten D Mertz, Zhihong Yang, Xiu-Fen Ming   +9 more
doaj   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Arginase-2 mutation reduces muscle fibrosis.

, 2013
(A) Mdx mice lacking arginase-2 expression demonstrated decreased fibrosis in quadriceps (Quad) and diaphragm (Diaph) muscles. Arginase-2 mutation reduced fibrosis in diaphragm, longissimus dorsi (LD) and heart of wild-type mice. Sol  =  soleus.
Maria C. Jordan (364579), Tomomi Gotoh (9548), James G. Tidball (342481), Kenneth P. Roos (364583), Wayne W. Grody (364582), Michelle Wehling-Henricks (342479)   +5 more
core   +1 more source

A PD‐L1 Nanobody‐Engineered Synthetic RNA Virus Enhances Hepatocellular Carcinoma Immunotherapy by Interfering PCSK9 and Upregulating MHC‐I

Exploration, EarlyView.
A PD‐L1 nanobody‐engineered synthetic RNA virus (αPDL1‐VLPs/shPCSK9) is fabricated to inhibit PCSK9 and upregulate MHC‐I to facilitate T cells recognition of hepatocellular carcinoma (HCC). Moreover, αPDL1‐VLPs/shPCSK9 can recognize PD‐L1 and block the PD‐1/PD‐L1 pathway to prevent immune evasion, while promoting M2‐to‐M1 macrophages polarization ...
Chuyu Huang, Yun Ye, Yi Guo, Guozheng Liao, Linyi Luo, Lingwen Ding, Yingling Miao, Linping Zhao, Yongchang Ouyang, Shiying Li   +9 more
wiley   +1 more source

Th2 cytokines induce arginase activity and expression in mdx muscle macrophages.

, 2013
(A) Arginase activity of muscle macrophages isolated from mdx mice at various ages was measured following in vitro stimulation with either IL-4, IL-10, IL-13 or no cytokine. At least 3 experiments were performed with a minimum of 5 wells for each age and
Maria C. Jordan (364579), Tomomi Gotoh (9548), James G. Tidball (342481), Kenneth P. Roos (364583), Wayne W. Grody (364582), Michelle Wehling-Henricks (342479)   +5 more
core   +1 more source

Tetrahedral Framework Nucleic Acid Delivery of miR-210-3p Promotes Femoral Bone Regeneration Through EFNA3/AKT/STAT3-Mediated Immunomodulation. [PDF]

Cell Prolif
Schematic of tFNA‐miR‐210‐3p fabrication, macrophage regulation and femoral defect therapy: it enters macrophages, inhibits EFNA3 to induce M2 polarisation and boosts rat bone repair in vivo. ABSTRACT Persistent inflammation, insufficient vascularization and impaired osteogenesis limit the repair of critical‐sized femoral defects. Although microRNA‐210‐
Hu L, Xue K, Fang J, Cui W.
europepmc   +2 more sources

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

A nanobiosensor for the detection of arginase activity

, 2017
A nanobiosensor for arginase detection was designed and synthesized. It features a central dopamine-coated iron/iron oxide nanoparticle to which sulfonated cyanine 7.0 is tethered via a stable amide bond.
Troyer, Deryl L., Malalasekera, Aruni P., Bossmann, Stefan H., Wang, Hongwang, Udukala, Dinusha N., McLaurin, Emily J., Yapa, Asanka S., Ortega, Raquel, Shrestha, Tej B., Alshetaiwi, Hamad, Samarakoon, Thilani N.   +10 more
core   +1 more source

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source

Lactobacillus derived small RNAs protect against Klebsiella pneumoniae infection

iMeta, EarlyView.
This study reveals that plant‐derived natural products confer protection against carbapenem‐resistant Klebsiella pneumoniae (CRKP) infection via remodeling the gut microbiota, with Lactobacillus identified as the core beneficial genus. Mechanistically, Lactobacillus murinus (L.
Tingting Xu, Xiuying Tao, Dan Fang, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +5 more
wiley   +1 more source