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Journal of Molecular Medicine, 2015
Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine to ...
Yuan Yan, Sin +3 more
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Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine to ...
Yuan Yan, Sin +3 more
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Experientia, 1948
Nombreux sont les travaux qui traitent de la separation et de la purification de l'arginase. Le present travail decrit une methode de purification qui permet d'obtenir une arginase active contenant des traces d'impuretes (80% d'arginase active).
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Nombreux sont les travaux qui traitent de la separation et de la purification de l'arginase. Le present travail decrit une methode de purification qui permet d'obtenir une arginase active contenant des traces d'impuretes (80% d'arginase active).
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Assay and kinetics of arginase
Analytical Biochemistry, 1986A sensitive colorimetric assay for arginase was developed. Urea produced by arginase was hydrolyzed to ammonia by urease, the ammonia was converted to indophenol, and the absorbance was measured at 570 nm. The assay is useful with low concentrations of arginase (0.5 munit or less than 1 ng rat liver arginase) and with a wide range of arginine ...
C L, Garganta, J S, Bond
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Comparative properties of arginases
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996Arginase is a primordial enzyme, widely distributed in the biosphere and represented in all primary kingdoms. It plays a critical role in the hepatic metabolism of most higher organisms as a cardinal component of the urea cycle. Additionally, it occurs in numerous organisms and tissues where there is no functioning urea cycle. Many extrahepatic tissues
C P, Jenkinson +2 more
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British Journal of Pharmacology, 2009
Allergic asthma is a chronic inflammatory airways' disease, characterized by allergen-induced early and late bronchial obstructive reactions, airway hyperresponsiveness (AHR), airway inflammation and airway remodelling. Recent ex vivo and in vivo studies in animal models and asthmatic patients have indicated that arginase may play a central role in all
Maarsingh, Harm +2 more
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Allergic asthma is a chronic inflammatory airways' disease, characterized by allergen-induced early and late bronchial obstructive reactions, airway hyperresponsiveness (AHR), airway inflammation and airway remodelling. Recent ex vivo and in vivo studies in animal models and asthmatic patients have indicated that arginase may play a central role in all
Maarsingh, Harm +2 more
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Molecular and Cellular Biochemistry, 1980
We report here, for the first time the presence of arginase in human platelets. This enzyme has been partially purified and some of it properties studied. Its biological significance and its involvement in polyamine biosynthesis are considered.
V R, Villanueva, M, Giret
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We report here, for the first time the presence of arginase in human platelets. This enzyme has been partially purified and some of it properties studied. Its biological significance and its involvement in polyamine biosynthesis are considered.
V R, Villanueva, M, Giret
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Measurement of arginase activity
Analytical Biochemistry, 1968Abstract Current methods for determining arginase ( l -arginine amidinohydrolase, EC 3.5.3.1) activity involve the measurement of urea. The carbon dioxide evolved through the action of urease has been measured manometrically (1–3), although more frequently ammonia is determined by established but cumbersome procedures (4, 5).
J J, Hagan, R D, Dallam
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Purification and crystallisation of arginase
Biochimica et Biophysica Acta, 1958Abstract 1. 1. A reproducible method for the purification of arginase has been described. 2. 2. In the last stage of the purification crystals of arginase were obtained and recrystallised. 3. 3. The specific activity of the crystals was considerably higher than that of the solution from which they were obtained, and was only slightly ...
S J, BACH, J D, KILLIP
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Arginases in parasitic diseases
Trends in Parasitology, 2003Abstract Parasites have elaborated a variety of strategies for invading hosts and escaping immune responses. This article proposes that a common mechanism whereby different parasites escape nitric oxide (NO) toxicity is the activation of arginase. This leads to a depletion of l-arginine (substrate of NO synthase, resulting in lower levels of cytotoxic
Philippe, Vincendeau +4 more
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Biological Reviews, 1936
SummaryI. Arginase is a highly specific intracellular enzyme and requires that both the carboxyl and the guanidine groups shall be free if the substrate molecule is to be activated. The kinetics of arginase and its behaviour towards activators and inhibitors are very briefly discussed in the text.2.
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SummaryI. Arginase is a highly specific intracellular enzyme and requires that both the carboxyl and the guanidine groups shall be free if the substrate molecule is to be activated. The kinetics of arginase and its behaviour towards activators and inhibitors are very briefly discussed in the text.2.
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